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Research About The Biological Effect Of 1650Gs Static Magnetic Field On Mice

Posted on:2007-08-21Degree:MasterType:Thesis
Country:ChinaCandidate:L L HouFull Text:PDF
GTID:2120360185979447Subject:Radiation Medicine
Abstract/Summary:PDF Full Text Request
Object: To provide experimental data on utilization and protection of magnetic field, the long-term biological effect of 1650Gs static magnetic field was observed on mice.Methods and results: No obvious changes of appearance, feeding and movement were observed on mice irradiated by long-term 1650Gs static magnetic field. Peripheral hematogram, as well as proliferation index of bone marrow cells detected by flow cytometry, showed some impacts on hematopoietic system. Peripheral lymphocyte subpopulations were not effected. Splenic and thymic index or proliferation index showed that 1650Gs static magnetic field may increase splenic cell number and enhance proliferation ability of spleen and thymus. No electrolyte imbalances were observed. Blood sugar was transiently increased. Decreased cardiac enzymes were detected 1-2 month after irradiation with no signs of damaged heart function. Changes of hepatic enzyme spectrum and transiently decreased serum albumin and A/G implied that long-term 1650 Gs static magnetic field may damage liver function. Decreased serum cholesterol 3 month after irradiation may be related to damage liver function. Serum urea nitrogen and creatinine showed no damaged renal function of 1650Gs static magnetic field. HPLC showed that long-term 1650Gs magnetic field can change neurotransmitter level of brain. Routine pathological observation and PCNA immunohistochemical detection of mouse testis showed that reproductive ability of male mice may be affected.Conclusion: 1650Gs static magnetic field shows some biological effect on mice, especially enhanced immune function, damaged liver function and affected...
Keywords/Search Tags:Static magnetic field, Mice, Biological effect, Immunohistochemistry
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