Study On The Synthetic Technology Of Cefpiramide

Drugs that can cope with bacterial resistance will play an important role in the field of antibacterial research. Many derivatives of traditional antibiotics and new chemical entities with novel structures or targets have been reported abroad. Novel drugs can settle bacterial resistance more efficaciously by new antibacterial mechanism, which are designed on the basis of novel targets.Cefpiramide, a third-generation cephalosporin, has a relatively long half-life of 4.5 hours, plasma protein binding extensively and high biliary excretion with prototype. Cefpiramide can be used to treat the disease caused by susceptive Gram-positive and Gram-negative bacterias.Synthetic technology of cefpiramide is studied in this paper. Three synthetic routes were designed on the basis of relevant references, then their feasibilities were analysed. 4-Hydroxy-6-methylpyridine-3-carboxylic acid was gained from 4-hydroxy-methyl-2-pyrone by the reaction of condensation and rearrangement. (2R)-2-[[(4-hydroxy-6-methyl-3-pyridinyl)carboyl]amino]-2-(4-hydroxyphenyl)acetic acid was synthesized from 4-Hydroxy-6-methylpyridine-3-carboxylic acid and ethyl (R)-ethyl 2-amino-2-(4-hydroxyphenyl)acetate hydrochloride by the reaction of acylation. (R)-ethyl 2-amino-2-(4-hydroxyphenyl)acetate hydrochloride was gained from potassium (R)-2-[l-(ethoxycarbonyl)prop-l-en-2-ylamino]-2-(4-hydroxyphenyl)acetate by the reaction of hydrolyzation and esterification. Cefpiramide was produced from...