Synthesis, Characterization And Biological Activity Of Mixed Trialkyltin Compounds Containing Silicon

Most of trialkytin complexes have biological activity. Some of them were widely used as insecticide, bactericide and acaricide in agriculture. Some of mixed triorganotin complexes have multi-biologic activity. In order to study deeply on the relationships between the structure of mixed trialkyltin and their biologic activities. 11 new complexes containing silicon were synthesized and their methods of synthesis, structures, activities have been studied in this paper.(1) (Me₃SiCH₂) PhBuSnBr(2) (Me₃SiCH₂)Bu₂SnBr(3) (Me₃SiCH₂)Bu₂SnOCOArAr=-C₆H₄-H, -C₆H₄-F-p, -C₆H₄-Cl-p, -C₆H₄-Cl-m, -C₆H₄-Br-p, -C₆H₄-NO₂-p, -C₆H₄-OCH₃-p, -C₆H₄-CH₃-p, -C₆H₄-NO₂-m。Their structures were characterized by IR, ¹H NMR,¹³C NMR and MS. The results indicated that the Sn atom of (Me₃SiCH₂)Bu₂SnOCOAr is four-coordinated and didn't coordinate with oxygen of carbonyl. The activites which some of (Me₃SiCH₂)Bu₂SnOCOAr have been tested, The preliminary bioassay tests showed that these complexes have a good sterilization and antiacarid activity.This preliminary research on a series of novel silicon-containing trialkyltin compounds with biological activities may enrich the study of organotin chemistry, and provide scientific basis for the exploitation of sterilization and antiacarid organotin compounds.