Research On Safety Performance In Level-3 Biosafety Laboratory

Life Science is the leading subject in the 21st century of the world. The fruit of Life Science has involved in to all fields of society such as public medicine treatment and health, gene improving in agriculture, biomaterial and biochip in industry, bio-weapons in military etc. Some biologic techniques even are used by terrorists to make terrorist attacks. The biosafety problems and biosafety laboratory techniques are coming into the eyes of public. In these precondition, the paper gives all-round researches on the airflow distribution and the leakage of air while door moving in a level 3 laboratory (BSL-3), combining the experiments and computational fluid dynamics (CFD) simulations.In the subject, a full-scale lab was set up to test the recovery time and other airflow parameters data. The data are used for basic and validation of simulations. Using the math model, boundary and initial conditions, the paper gives contrast analysis of the recovery time, average air age, air exchange efficiency and contamination removal efficiency in the two exhaust modes which are up supply down side exhaust mode and up supply ceiling exhaust. The conclusions from data are as follows: in a controlled space, the contaminant removal time relates not only to the air distribution but also to the locations of the contaminant source. When the particles emit in all of the space symmetrically, the indexes containing recovery time, average air age, and air exchange and contamination removal efficiency in the ceiling exhaust are better than the down exhaust mode. While the contaminant source locates in the operation area below the height of 1.5m, the contaminative particles move to the down exhaust vent more quickly, thus the removal efficiency in down mode is better than the up mode, the average particle concentration in the breath region are lower and the particles the staffs'face captured is less.In order to prevent the leakage while the door opening, the paper designed a system with air transfer. In the help of experiments, the parameters for the system to operating stably and effectively were confirmed, and the contrast experiments proved that, the air transfer system can prevent the leakage when door opened.