The Research On Preparation And Property Of PVA/SA/ST Blend Hydrogel

This paper has introduced the background,theory of the hydrogel,and the hydrogels PVA and SA.We have optimized the concentration of the PVA,SA,ST,CaCl₂ by the preparation ways of dropping method and detected the gelling time, drying time,particle size and distribution.We have characterized its morphological property by SEM.Then we use the blend hydrogels to load Albumin and Tetracycline,calculated the drug-loading rate and entrapment rate, and gave a study on the external-load-drug experiment.Main results were as follows:1.In the preparation process,we get the result of the concentration of the polyvinyl alcohol,sodium alginate,starch and calcium chloride solution through Orthogonal analysis is 14wt%,3.5wt%,8wt%,0.1M,the gelling time is 20-25min,the drying time is 90min,the distribution is 0.94mm-1.06mm,and the particle size is 0.998mm2.With the observation of SEM,the hydrogels like a round ball,has smooth surface,the size of the hydrogels is about 1mm.3.The hydrogels in a simulated gastric juice(pH1.4 HCl buffer solution) in almost no swelling;By comparison with simulating colon solution(pH7.4 PBS buffer solution),the hydrogels beads swelled the volume bigger in simulated intestinal juice(pH6.8 PBS buffer solution).With the temperature increasing,the hydrogels swelling bigger,so the temperature has an importance to the SR of hydrogels,but the body temperature of 37℃is the best temperature.4.We detected that,after in simulated gastric juice(2hr),the dissolution of the hydrogels reach to 14.5%.After in simulated intestinal solution(4hr),the dissolution reach to 25.6%.After in simulated colon solution(2hr),the dissolution of the hydrogels reach to 100%.By comparison with simulating gastric solution, the hydrogels bead swelled the volume bigger and released the drug faster in pH6.8 PBS and pH7.4 PBS.Through the stomach,small intestine and the colon, hydrogels can be identified completed dissolution.5.With the concentration of BSA increased,drug loading decreased.10mg/ml of the drug-loaded hydrogels have the highest drug loading to 81.1%.With the concentration of BSA increased,encapsulation efficiency increased,50mg/ml of the drug-loaded hydrogels have the highest encapsulation efficiency,reaching 37.9%.6.With the concentration of Tetracycline-HCl increased,drug loading increased.5mg/ml of the drug-loaded hydrogels have the highest drug loading to 1.79%.With the concentration of Tetracycline-HCl increased,encapsulation efficiency decreased,1mg/ml of the drug-loaded hydrogels have the highest encapsulation efficiency,reaching 42%.7.By comparing the release of the two drugs,we found that hydrogels containing BSA demonstrated good drug-control-release.The simulated small intestinal juice and simulated colonic fluid have much influence on drug release in hydrogels containing Tetracycline-HCl,which may be inferred that hydrogels containing Tetracycline-HCl drug release mechanism of hydrogel mainly proliferation.Obviously this can not be as microspheres and bovine serum albumin to control drug release so effective,but also requires further study.8.In the process,we found that the blend hydrogel have good release-control effect,so we can concludede the PVA/SA/ST blend hydrogel can be applied to the oral drug carrier.