Synthesis Of Diaryl Propargylamines And 1,4-benzodioxins Catalyzed By Transition Metals

There are two parts in this thesis, one is the copper-catalyzed three-component synthesis of diaryl propargylamines, and the other is the iron-catalyzed stereoselective synthesis of 1,4-benzodioxins.In part one, a convenient copper-catalyzed three-component reaction of aldehyde, phenylacetylene and diarylamine is developed. The reaction provides an efficient protocol to diaryl propargylamine derivatives in good to high yields with low catalyst loading (2mol%). Eleven desired products were synthesized. All new compounds were characterized by 1H NMR,13C NMR and HRMS spectroscopy.In part two, we have studied the reaction of the iron-catalyzed procedure for the formation of 1,4-benzodioxin derivatives. A series of 1,4-benzodioxin derivatives can be stereoselectively synthesized in the presence of iron catalyst. Nine desired products were synthesized in good yields, These compounds were characterized by 1H NMR, 13C NMR spectroscopy.