Study On Metal - Organic Skeleton Material Based On Amino Acids As High Performance Liquid Chromatographic Chiral Stationary Phase

Chirality metal-organic frameworks（CMOFs） possess diverse structure, chiral channel and easy functionalization to be attracfive as novel hybrid molecular materials used for separation. This dissertation focused on expanding CMOFs constructed from amino acids as chiral stationary phases for HPLC chiral separation.The main works are summarized as follows:1) {[Co（L-trp）（bpe）（H₂O）]·H₂O·NO₃}n was synthesized, which was used as chiral stationary phase for HPLC separation. Some impact factors（mobile phase composition, flow rate, sample volume and column temperature） for enantioseparations had been discussed. The experimenttal results showed that the Co-Trp-CMOF column possessed good separation ability for 11 racemic compounds and 3 positional isomers, which proved that Co-Trp-CMOF was practicable to use as a novel HPLC stationary phase.2) [Zn（L-tyr）]n（L-tyrZn） 、 [Zn₄（btc）₂（Hbtc）（L-His）₂（H₂O）4]·1.5H2 O and{[Zn₂（L-trp）₂（bpe）₂（H₂O）₂]·2H₂O·2NO₃}n} were synthesized. They were used as chiral stationary phases for the HPLC, respectively. Three kinds of Zn-CMOF columns possessed excellent enantioselective recognition ability, too. Therefore,Zn-CMOFs hold a good application prospect in the chiral separation.3) We also synthesized [Co₂（L-Trp）（INT）₂（H₂O）₂（ClO4）]、[Co₂（sdba）（L-Trp）₂]and [Co（L-Glu）（H₂O）·H₂O]∞, which were prepared into three chiral columns,respectively. Some racemates and position isomers were separated on three Co-CMOF columns. This resarech expanded the chromatographic application and practical significance of CMOFs.