Clinical And Experimental Study On Treatment Of Children With Cough Variant Asthma By Qufeng Tongluo And Huatan Cough

Cough variant asthma, also known as cough asthma, is a chronic cough as the only or major clinical manifestations of the disease. The name of cough variant asthma (CVA) was first proposed by Glauser and the main performance of the disease was reported.. The pathogenesis of this disease is not clear, and many scholars believe that the same mechanism of asthma.The purpose of this study aims at the analysis of cough variant asthma in children with the syndrome characteristics, resulting in cough variant asthma syndrome elements for pathogenic wind infestation, phlegm dampness, and Professor Xu rongqian in children with cough variability asthma etiology and pathogenesis of knowledge, and the use of Qufeng Tongluo, cough phlegm method for clinical and experimental research, to investigate the tutor Xu rongqian Professor Qufeng collaterals, relieving cough and phlegm method in the treatment of cough variant asthma experience and mechanism.Methods:1 A collection of cough variant asthma patients and four diagnostic information and sorting, analysis of each symptom and syndrome distribution, the symptoms and signs of principal components are chosen and of pathogenesis factors were analyzed.2 To use supplemented Ligusticum scorpion dispersion were performed to observe the symptoms and signs of efficacy for treatment of cough variant asthma (CVA) and analyze the clinical effects of treating cough variant asthma Qufeng Tongluo, relieving cough and phlegm method. 3 A cough variant asthma rat model, with the experience of my tutor’s clinical treatment of CVA to intervene in rats, using the technology of modern medicine on rats, the pathological changes of lung tissue and airway smooth muscle change and the serum IL-4/IFN-gamma levels were detected, from the cellular and molecular level study of Qufeng Tongluo, cough phlegm method.Results:1 Pathogenesis of 1 in children with CVA was mainly for phlegm dampness, wind evil commit, mutual interference of wind phlegm, lung and blood stasis, lung loses Xuan and cough, also wind evil can invasion of nasal orifices and throat.2 In the symptoms and signs of the total score difference comparison, compared with before treatment,1 week of treatment, treatment for 2 weeks were significant difference (P<0.05); treatment 2 weeks and treatment 1 week compared with significant difference (P<0.05), show that before and after the treatment, the symptoms and signs improved significantly. Cough symptom scores the difference comparison shows that, compared with before treatment,1 week of treatment, treatment 2 weeks cough were improved obviously, and the difference is statistically significant (P<0.05), compared with 2 weeks compared with 1 week of treatment, cough was significantly improved, the difference is statistically significant (P<0.05).3Experimental study of Chinese medicine treatment group and western medicine group were significantly higher than the level of IL-4 decreased in model group (P<0.05), the high dose of Chinese medicine group was the most obvious, compared with the western medicine group, Chinese medicine high dose group serum IL-4 value decreased, no significant difference (P>0.05); traditional Chinese medicine treatment group, western medicine group was significantly higher than model group IFN-y increased (P<0.05), compared with the western medicine group, Chinese medicine high dose treatment group serum gamma IFN value increased relatively, no significant difference (P>0.05); traditional Chinese medicine treatment group, western medicine group than in the lung tissue of model group α-SMAmRNA expression significantly decreased, with significant difference (P<0.05), compared with the traditional Chinese medicine, western medicine group, high dose treatment group had no significant difference in the expression of α-SMAmRNA (P>0.05).4Compared with the normal group, the rest of the group rat bronchial wall swelling mucosa, damage and inflammatory cell infiltration were more obvious. Compared with the model group, western medicine group and Chinese medicine group and pathological manifestations are reduced to a different extent, in the high-dose group of Chinese medicine relieve level is the most obvious.Conclusion:1 Cough variant asthma pathogenesis mainly for lung syndrome characterized by wind, wind invading the lung, phlegm dampness.2 Qufengtongluo, Huatanzhike method can effectively alleviate the symptoms of cough in children with CVA, clinical curative effect.3 Qufeng Tongluo, cough phlegm method can regulate CVA rat IL-4 and IFN-γ, inhibit airway a-SMAmRNA expression, to alleviate the airway inflammation, inhibit airway remodeling and verify the clinical curative effect.