Study On The Related Factors Of Psoriasis Eczema And The Regularity Of Traditional Chinese Medicine In Damp - Heat Syndrome

Psoriasis(PS) is a kind of chronic inflammatory skin disease characterized by scaly,erythematous patches.The article is to summarize the symptome distribution in traditional Chinese medicine(TCM) and the facters of the eczema-like psoriasis(PS), also to explore the Chineses medicine laws of the damp-heat syndrome existing in the psoriasis,to supply a new better understanding of the eczema-like psoriasis.[Objective]To describe the symptome distribution in TCM especially damp-heat syndrome and the facters of the eczema-like psoriasis using clinical investigation,and to determine the key facter through univariate and multivariate analysis through possible facters,also to explore the Chineses medicine laws of the damp-heat syndrome through searching relevant literature.【Methods】1.Collecting the clinical information of the patients who was diagnosis of psoriasis at the Air Force General Hospital from November 2014 to January 2015 and describing symptome distribution in TCM.By univariate and multivariate Logistic analysis of possible indexes, such as gender, age,dietary habit, family history,body mass index,psoriasis area and severity index and so on,to select the key facter in the eczema-like psoriasis.2.Collecting the literature which is fit from CNKI dasebate and WanFang Data about the treatment of damp-heat syndrome psoriasis, a total of 24 target documents are selected at last, extracting the prescription and the drug composition.Analyzing medication rules by using SPSS 17.0 software and Microsoft SQL Server.[The result]1.Univariate analysis shows that age,gender,BMI,age of onset,infection facters,spicy addiction differ statistically between the eczema-like psoriasis group and the opposite.The eczema-like psoriasis group have higher age,age of onset,BMI,as well as more men patients.However the group without eczema-like change have high frequency about infection facters and spicy addiction.The further multivariate Logistic analysis show that relevent facter is is the BMI (OR=1.109,5%CI:1.016-1.211)and infection facter(OR=0.240,95%CI=0.106-0.541).BMI is the risk facter meaning that eczematoid psoriosis is prone to merge.Patients with infection facters trends to accompany eczema-like psoriasis.2.Damp-heat syndrome accounts for 87.1% in eczema-like psoriasis group and only 7% in the group without eczema-like change.Damp-heat syndrome could accompany blood heat syndrome with the highest frequency,blood deficiency syndrome,blood stasis syndrome and no group difference is not statistically significant.3.Through the analysis of the Chinese medicine on the treatment of damp-heat syndrome we find that the drug properties are mainly bitter in flavor and cold in nature,acting on the Liver and Stomach Meridian.There are 23 Traditional Chinese Medicines including one Heat-Clearing and Fire-Purging Durg Fructus Gardeniae,five Heat-Clearing and Dampness-Drying Drugs such as "Radix Scutellariae,Cortex Phellodendri,Cortex Dictamni,Radix Gentianae,Radix Sophorae Flavescentis",four Heating-Clearing and Detoxicating Drugs such as "Flos Lonicerae,Rhizoma Smilacis Glabrae,Rhizoma Paridis,Caulis Lonicerae",four Heat-Clearing and Blood-Cooling Drugs such as "Radix Rehmanniae Recens,Cortex Moutan Radicis, Radix Paeoniae Rubra,Radix Lithospermi",one Dampness-Removing Drug "Rhizoma Atractylodis",seven Drugs for Inducing Diuresis and Ecreting Dampness such as "Semen Coicis, Fructus Kochiae, Rhizoma Alismatis, Rhizoma Dioscoreae Hypoglaucae,Herba Artemisiae Scopariae,Semen Plantaginis, Caulis Akebiae",one Drug for Invigorating Qi Radix Glycyrrhizae. Rhizoma Smilacis Glabrae is the most important drug having the maximum use frequency.The combination of Rhizoma Smilacis Glabrae and Cortex Dictamni also has the maximum use frequency.Longdan xiegan decoction,huanglian jiedu decoction,xijiao dihuang decoction are frequently used.The main method is clearing heat and promoting diuresis as well as cooling blood and removing toxicity.It should be paied more attention to remove toxicity and dampness,also the amount of dampness and heat,distinguish excess from deficiency of zangfu.【conclusion】1.Damp-heat syndrome constitutes the majority of eczema-like psoriasis.Damp-heat syndrome could accompany blood heat syndrome,blood deficiency syndrome,blood stasis syndrome.It should be paied more attention.2.Psoriasis patients’skin lesion have more tendency to be eczema-like with higher weight meeting the theory of fat people having more phlegmy wet.Psoriasis patients’skin lesion is not prone to be eczema-like with infection facter including tonsillitis and infection of the upper respiratory tract.3.When treating damp-heat syndrome,we should consider liver and stomach. The main method is clearing heat and promoting diuresis as well as cooling blood and removing toxicity.It should be paied more attention to remove toxicity and dampness,also the amount of dampness and heat,and to distinguish excess from deficiency of zangfu viscera.