| OBJECTIVEHepatitis B cirrhosis (HBC) has characteristics of long course of disease, high infectivity, complicated complications, being easy to relapse. Since effective treatment hasn’t been matured, it leads to different degrees of psychological problems to the patients. TCM has a unique understanding of etiology and pathogenesis of HBC, which could improve symptoms, control disease progression and enhance the quality of life. By using the idea of preventive treatment of disease and syndrome differentiation and treatment can obtain well clinical curative effect, medical community pays more attention to TCM. This research explores 101 cases of compensated HBC patients, studies TCM syndrome characteristics, etiology and pathogenesis, investigates Five-Pattern Personality characteristics and the situation of anxiety as well as depression. This may lead to explore the psychological health and personality temperament type, which can help to clinic treatment.METHODSWe summarize common TCM symptoms, as well as the classification and quantification compensated of HBC. Then establish our final questionnaire based on experts advices. The eligible 101 clinical cases come from patients treated in Dongzhimen hospital and the Chinese people’s liberation army 302 hospital. We explore the syndrome of characteristics, etiology and pathogenesis by using syndrome differentiation and syndrome factor analysis research, we also compare the differentiation of compensated HBC patients’ mental health state and Five-Pattern Personality dimensions with national norm.RESULTSThe 101 cases male and female incidence ratio of patients is 2.61:1. It is mainly concentrated in 41 to 50 years of age, office work personnel, education in undergraduate course or even above. People with type A and type B blood may have higher risk (22.8%) at suffering from compensated HBC. According to syndrome differentiation,101 cases are classified by five patterns, syndrome of liver qi stagnation (61.4%), syndrome of Yin deficiency of liver and kidney (49.5%), syndrome of blood stasis resistance collaterals (32.7%), syndrome of accumulation of damp heat (26.7%), syndrome of Yang deficiency of spleen and kidney (5.0%), there are 62 cases of patients with symptoms of spleen deficient at the same time. Through factor analysis,101 cases are identified with composite syndrome, followed by: syndrome of spleen deficiency and dampness with qi stagnation (12.9%), syndrome of liver phlegm-heat and spleen deficiency (12.9%), syndrome of liver blood stasis with heat stagnation(12.9%), syndrome of spleen deficiency and kidney deficiency (11.9%), syndrome of damp-heat accumulation and liver Yin deficiency (9.9%), syndrome of damp-heat accumulation and qi stagnation (9.9%), syndrome of spleen deficiency and dampness with Yang deficiency (7.9%), syndrome of liver and gallbladder damp hot (7.9%), syndrome of liver blood stagnation with liver-yang hyperactivity type (7.9%), syndrome of stagnation of liver qi and spleen deficiency with blood stagnation (5.9%).101 cases’anxiety index is (39.55±9.66), there are 31 examples have anxiety. Among the crowd,29 cases are mild anxiety,2 cases are moderate. Patients who have a course of disease in 0.5 to 5 years get highest anxiety score (41.80±7.153). Meanwhile,101 cases’depression index is (44.05±9.83), there are 36 examples in depressed mood. Among crowd,30 cases are mild depression, moderate in 5 cases, severe in 1 case. The results also show that anxiety and depression stay in a constant companion:14 cases have pure anxiety,19 cases have depression alone, and 17 cases have anxiety with depression. In all cases, the scores of less yin are higher than national norm (P＜0.05), while the scores of yin-yang balanced personality are lower than national norm (P<0.05). The scores of each personality in male groups show no difference with normal. However, the scores of greater yin in female group are significantly higher than national norm.CONCLUSIONS1. The pathogenesis of compensated HBC patients is complicated, one of the cores is spleen deficiency, pathological factors include spleen deficiency, kidney deficiency, Yin deficiency, dampness and hot, blood stagnation, and qi stagnation. It mainly locates in liver, spleen and kidney, the major syndromes distribution of diseases are syndrome of liver qi stagnation, syndrome of Yin deficiency of liver and kidney, syndrome of blood stasis resistance collaterals, syndrome of accumulation of damp heat, syndrome of Yang deficiency of spleen and kidney.2. The patients with compensated HBC showed different degrees of anxiety and depression.3. The patients with compensated HBC have higher scores in less yin group than normal, lower in yin-yang balanced group. Groups of syndrome of Yin deficiency of liver and kidney, syndrome of blood stasis resistance collaterals, as well as female have higher scores in greater yin than national normal.
|
PDF Full Text Request