Expression Of MTDH, VEGF And Cyclin G1 In Triple - Negative Breast Cancer And Its Clinical Significance

Purpose:To study the expression and clinical significance of MTDH,VEGF andCyclin G1in triple-negative breast cancer tissue.Material and method:Tissue samples of168breast cancers(include112TNBCtissue and56Non-TNBC tissue),10breast fibroadenomas and15normal breaststissues were collected.Postoperative specimens were investigated byimmunohistochemistry for MTDH,VEGF and Cyclin G1expression.Correlationsamong the expression of MTDH,VEGF and Cyclin G1expression andclinicopathological factors were studied.Results:1.MTDH was mainly expressed by membrane and cytaplasm of breast cancer cell.Theexpression rate of breast cancer tissues was57.1%.Among this,the expressionrate of TNBC tissues was64.3%,the Non-TNBC tissues was42.9%,the compartivedifference was statistically significant(P=0.008);There was also astatistically significant compared with breast fibroadenoma(P=0.003);andnormal mammary gland (P=0.000).MTDH expression was correlated with the stausof tumor size (P=0.008),BMI values (P=0.009),lymph node metastasis(P=0.001),pathological staging (P=0.031),recurrence and metastasis(P=0.030),and the expression of p53（P=0.000）and ki67（P=0.023）;2.VEGF was mainly expressed by cytplasm of breast cancer cells.The expressionrate of breast cancer tissues was49.4%.Among this,the expression rate of TNBCtissues was56.3%,the Non-TNBC tissues was35.7%,the compartive difference wasstatistically significant(P=0.012);There was also a statisticallysignificant compared with breast fibroadenoma(P=0.012);and normal mammarygland (P=0.000).VEGF expression was correlated with the staus of lymph nodemetastasis(P=0.000)， pathological staging(P=0.003)， recurrence andmetastasis(P=0.029),and the expression of ki67(P=0.019);3.Cyclin G1was mainly expressed by Breast cancer cells nucleus of theorganization cytoplasm.The expression rate of breast cancer tissues was 52.4%.Among this,the expression rate of TNBC tissues was58.9%, the Non-TNBCtissues was39.3%,and the compartive difference was statistically significant(P=0.016);There was also a statistically significant compared with breastfibroadenoma(P=0.012);and normal mammary gland (P=0.000).Cyclin G1expressionwas correlated with the staus of lymph node metastasis(P=0.002)， recurrenceand metastasis(P=0.003),and the expression of P53(P=0.011);4.Statistically significant correlation was found between MTDH and VEGFexpression（r=0.356，P＜0.05）；Statistically significant correlation was foundbetween MTDH and Cyclin G1expression（r=0.325，P＜0.05）;5.The higher expression rate of MTDH showed a lower DFS than the lower expressionrate of MTDH（59.7%vs.80.0%）（P=0.023)；meanwhile, the higher expression rateof MTDH showed a lower OS than the lower expression rate of MTDH（73.6%vs.92.5%）(P=0.017);6.The higher expression rate of VEGF showed a lower DFS than the lower expressionrate of VEGF（58.7%vs.77.6%）(P=0.025)；meanwhile, the higher expression rateof VEGF showed a lower OS than the lower expression rate of VEGF（73.0%vs.89.8%）(P=0.024);7.The higher expression rate of Cyclin G1showed a lower DFS than the lowerexpression rate of Cyclin G1（56.1%VS.82.6%）(P=0.003)；meanwhile, the higherexpression rate of Cyclin G1showed a lower OS than the lower expression rateof Cyclin G1（71.2%VS.89.1%）(P=0.024).Conclusion：1.MTDH and VEGF may be correlated with tumor angiogenesis and progression；2.MTDH and Cyclin G1may be correlated with tumor cell cycle control syst；3.VEGF and Cyclin G1may be not correlated with cell cycle control syst；4.Patients with MTDH,VEGF and Cyclin G1high-expression show far a lower DFSand OS.5.MTDH,VEGF and Cyclin G1has the potential to be a valuable prognostic factorsin patients with TNBC.