Establishment Of Clinical System Of Thoracoscopic Lobectomy And Its Effect On Cytokines

To explore the lobectomy techniques of video-assisted thoracoscopic surgery (VATS). The clinical application of lobectomy by VATS should be research on feasibility, safety and effectiveness. It also will be compared the effect of blood cytokines treated non-small cell lung cancer with traditional open thoracotomy (OT) and VATS perioperative period. From October 2013 to August 2015. all of 146 patients were underwent lobectomy by VATS and thoracotomy.73 cases were done by complete VATS and others by thoracotomy. Video-assisted thoracoscopic surgery lobectomies were preformed though three small incisions in the chest. The procedures, technology and methods were set up. We retrospectively compared two groups’ clinical surgical outcomes and evaluated video-assisted Thoracoscopic surgery. The 48 cases early non-small cell lung cancer patients is divided into two groups, OT group 22 cases, VATS group 26 cases. The concentration of the inflammation factor IL-6, IL-8, IL-10、IL-1β、IL12P70 and TNF-alpha in blood were examined by flow cytometer at preoperative 4 hours, and postoperation lhour,2,3 and 7 days. While sVEGFR1 and sVEGFR2 concentrations were examined with enzyme joint immune adsorption (ELISA) method at preoperation and postoperation 1,3 and 7 days in the blood. The effects of cytokines concentrations were compared between groups. Results 73 cases of VATS and 73 cases of OT lobectomy were preformed successfully from October 2013 to August 2015. Postoperative hospitalization time, complications, bleeding during operating room,3 days postoperative drainage and moved thoracic drainage time were compared between VATS and OT groups. There were significant differences in the two groups. The numbers of lymph node dissection, postoperative complications and postoperative pathologies were not significant differences. The peroperation serum concentrations of IL-6, IL-8, and IL-10 were found significantly higher than preoperative. Same time sVEGFR1 and sVEGFR2 concentration was reduced significantly. To compare OT, VATS can significantly reduce stress higher IL-6, IL-10 concentration and slightly declines sVEGFR2 concentration postoperative. Completely video-assisted Thoracoscopic Lobectomy is safe, minimally invasive, effective and technically feasible procedure. It has an advantage over traditional OT. VATS has lower acute stress response and may be smaller metastasis and recurrence after surgery.