| A series of composite materials formed from acetylated collagen and GAG (chondroitin 4-sulphate and hyaluronic acid) has been used for cellular proliferation. The structures and properties of the composite materials, such as mechanical properties, cellular cultivation and zoology experiments were studied. The results showed that both the chemically modified collagen and the collagen composites (5?O%Ch4S), in comparison to native collagen, are relatively good substrates. The bio-compatibility was greatly improved and the degrading speed of collagen sponges was slowed down. With the increasing concentrations of GAG, the substrates proved to be more profitable to cellular attachment, growth and proliferation. New connective tissue matrix in the defects was inducted to forming, which would quicken the course of concrescene. When GAG was incorporated into acetylated collagen, according to a certain proportion (8%Ch4S and 2.5%LIA), the colligation properties of composite membrane would be best fit to the demands of artificial skin. |
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