The Study On The Correlation Of Location Of Myocardial Perfusion Defects Of The Left Cardiac Function Using Myocardial Perfusion SPECT

Objectives: The association of the location of myocardial perfusion defects with the resulting changes in the cardiac function has long been of great interest, and a number of studies have been done. However, the conclusions are often questioned because of the limitations of the methods used in these studies. Myocardial perfusion imaging is relatively accurate in evaluating myocardial ci efec ts. Background: This study was designed to observe the effects of myocardial perfusion defects at different locations on the systolic and diastolic functions of the left heart. Methods: One hundred and eighty-eight patients who underwent a stress /rest sestamibi myocardial perfusion imaging. Cardiac function was calculated fromradionuclide ventriculography arid echocatdiography. The correlation of the location of the defects and the changes in cardiac functions was analyzed in these patients. The relevant cardiac indices included LVEF, CO, CI, PFR, PER, ED ESA/E, and ventricular wall motion. Statistical analysis was performed using SPSS software. Results: In 97 of 188 patients with myocardial petfusiori defects, LVEF, PER, CO and CI was lower than normal, EIJV and ESV was greater than riormal. The perfusion defects located on anterior or apical ventricular wall is associated with decrease in LVEF, CO, CI, PER and PFR, and with increase in EDV and ESV The perfusion defects of posterior ventricular wall affects all the above indices except for CO. The perfusion defects located on inferior or septic ventricular, wall gave rise to decrease in LVEF and increase in EDV and ESV The perfusion defects of lateral ventricular wall did not seem to affect any of the indices. Reduced ventricular wall motion was seen in anterior or apical ventricular wall that with perfusion defects. The close correlation is found between LVEF and PFR, PER, EDV, ES CO and CI. The correlation is variety with the perfusion defects of ventricular wall. Conclusions: 1. Myocardial perfusion defects affect the left ventricular function. LVEF, PER, EDV, ES CO, CI and reduced ventricular wall motion are the most sensitive j nd ices. 2. The perfusion defects of the anterior or apical ventricular wall produces the most effect on the left cardiac function, followed by the perfusion defects on the posterior, septic and inferior ventricular walls, whereas lateral ventricular wall defects has minimal effect.3. Close correlations are found among the cardiac indices. Therefore,comprehensive interpretation and analysis are needed in evaluating cardiacftinc tio ns.To our knowledge, our study may be the first study in which myocardialperfusion SPECT was used to explore the changes in cardiac functions causedby myocardial perfusion defects at different locations. It provides usefulclinical infOrmation for the diagnosis, treatment, and prognostic evaluation ofheart disease.