The Expression And Significance Of Heat Shock Protein 70 In Human Hepatocellular Carcinoma And The Effects Of Gene Transfection On The HepG2 Hepatocarcinoma Cell

Heat shock proteins (HSPs) are highly conserved proteins expressed in prokaryotes and eukaryotes under normal and abnormal condition. HSPs play an important role in protecting proteins by assisting in the refolding of damaged proteins or facilitating the degradation of damaged proteins unable to repair. Recent study showed that HSPs also play an important role in carcinogensis of many tumors, however, little is known on the expression and significance of HSP7O and its potential use in treatment of hepatocellular carcinoma (11CC). Our studies have focused on the roles of HSPs in the pathogenesis of tumor and infectious diseases. On the base of our previous findings, (1) the expression of HSP7O protein and mRNA in 70 cases of 11CC tissues had been detected with immunobistochemistry and in situ hybridization. The results showed that about 81 .5%(57170) of 11CC cases and 54.1 %(20/37) peri-carcinomatic tissues were positive for HSP7O with the cytoplasm and/or nucleus localization. The positive rate of HSP7O in 11CC was significantly higher than that in peri-carcinomatic tissues (p