| Objective: To evaluate the influence of ovarian stimulation by clomiphene citrate(CC)and CC+human menopausal gonadotropin (hMG) +human chorionic gonadotropin(hCG) on endometrial histology.Methods: Thirty rats were randomly allocated into 3 groups, each group with 10 rats. (1) CC group: clomid serophere was given only. (2) CC+hMG+hCG group: clomid serophere was given first for desensitizing the pituitary, then hMG and hCG were added for ovarian stimulation. ( 3) Control group was given with saline of same volume as groups CC and CC+hMG+hCG on the same time schedule. Endometrial histology were investigated by light microscope.Result: Compared to the control, the changes of endometrial histology in group CC and group CC+hMG+hCG was significantly different. Delayed endometria maturation was frequently found in group CC and group CC+hMG+hCG (p<0.01) . But there were not difference between CC and CC+hMG+hCG group (P>0.05) .Conclusion: Ovarian stimulation protocols can considerably influence the degree of endometrial maturation , therefore they can influence the embro implantation . |
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