The Study Of The Antiangiogenic Activity Composition From Equisetum Hiemale L.

Now, chemotherapy of tumor enter in plateau. Find out effective tumor angiogenic inhibitor has become a hot point in researching new drug for tumor.For exploring if the Equisetum hiemale L. has antiangiogenic activity , here we have a test for ethyl acetate extracted from Equisetum hiemale L. on angiogenic activity using the method of chorio allantioc membrane.Base on this pharmacodynamics test, we study the chemical component of Equisetum hiemale L. Preliminary pharmacodynamics study show, ethyl acetate extracted from Equisetum hiemale L. can inhibit the produce of new blood vessel in tumor in some degree.Three compounds were isolated from the overground part of the dried Equisetum hiemale L. by the methods of solvent extraction and silicagel column chromatography etc. According to the physical and chemical characters, spectrum analysising and comparing with standard control, 3 chemical compounds' structure were identified, they are Nonadecanoic acid, Kaempferol and Quercetin. Among them, Nonadecanoic acid is first isolated from Equisetum hiemale L.At present, founded angiogenic inhibitor mainly included biological product, endogenous angiogenic inhibitor, chemical drug and trad.Ch.medicine and so on. Among them research on trad.Ch.medicine is rare. This results provided scientific basic for exploring and applying more effective angiogenic inhibitor.