Study Onthe Clinical And Pathological Features, Molecular Mechanism Of Biologic Behavior And Prognosis In Pituitary Adenomas

Objective To study invasiveness standard, invasive behavior mechanism and prognosis of pituitary adenomas by analysis of the clinical and pathological features of invasive pituitary adenomas and expression of E-cad,nm23,MMP-9 and TIMP-1. Methods Forty-seven surgically removed pituitary adenomas was divided into invasive group twenty-three cases and noninvasive group twenty-four cases on the basis of radiological and intraoperative observation. The expression characteristics of above-mentioned gene proteins and clinical and pathological features were determined and compared between the two groups with follow-up data.Results Significant clinical and pathological difference existed between two groups in tumor size(P＜0.01), functional and endocrine classification(P＜0.05),except in age ,interval time between symptom appearance and admission, incidence of mitosis, nucleus atypia , cell pleomorphism and tissue necrosis. Moreover, proportion of invasive adenoma increased with volume of tumor(P＜0.01).The invasive group had a significantly lower expression of E-cad and nm23 than that of noninvasive group,endocrine inactive group expressed significantly lower E-cad than endocrine active group(P＜0.05); there was a negative correlation between expression of E-cad and grade of tumor volume(P<0.05). In addition, the invasive group had a significantly higher expression of MMP-9 and proportion of MMP-9 overexpressing TIMP-1 than that of noninvasive group(P＜0.05). In multi-factor analysis, volume, nm23 and MMP-9 had a significant effect on invasiveness of pituitary adenomas(P＜0.05).Conclusion E-cad, nm23, MMP-9 may play a key role in occurrence andprogress of invasiveness in pituitary adenomas. Analysis of the clinical and pathological features and expression characteristics of E-cad, nm23, MMP-9 of pituitary adenomas may better evaluate invasiveness and prognosis of pituitary adenomas.