The Effects On The Perinatal Newborn In Intrahepatic Cholestasis Of Pregnancy

Objective To study the effects on perinatal newborn with ICP. Methods Collect 72 cases of pregnant women with ICP, who delivered by cesarean section, from January 2000 to December 2002. Observe the amniotic fluid meconium contamination, fetal distress, premature delivery, asphyxia of newborn, neonatal aspiration pneumonia .70 cases of normal pregnancy of similar age, who delivered by cesarean section, were used as control group .Study the ultrastructure of the placental tissue with the electronic microscope. Consult The percentage of amniotic fluid meconium contamination, fetal distress, premature delivery, asphyxia of newborn, neonatal aspiration pneumonia respectively is 30.56%.23.61%, 16.67%,5.56%,16.67%, which are significantly higher than that in control group (P<0.05-0.01) There is obvious pathologial change in the placental tissue ultrastructure of case group. Conclusion ICP can induce premature delivery, fetal distress, asphyxia of newborn, amniotic fluid meconium contamination, neonatal aspiration pneumonia. The pathological change of the placental tissue ultrastructure closely relate to the prognosis of perinatal newborn.