Clinical Significance Of P53 Protein Expression, Estrogen Receptor And Progesterone Receptor In Breast Cancer

Objective By studying the immunohistochemical analysis of P53, estrogen receptor and progesterone receptor in paraffin-embedded tissue, the relationship between the expression of P53 and the pathological character (i. e. histology type, infiltration and regional lymph node status) of breast cancer was explored, meanwhile the objective parametic-indicator of the prognosis of the patient was provided.Methods The information of 436 cases of healed breast cancer patients evidenced by pathologic diagnoses from the Department of Pathology of Affiliated Hospital of Qingdao University Medical College during 1998 to 2000 was collected to screen 333 cases with relatively completed data. Then P53, ER and PR in paraffin-embedded tissue were stained with the usage of LSAB immunohistochemical method. Estabilsh a cumulative database for database software with Microsoft Excel 2000, and analyze the relationship between the positive expression of P53, ER and PR and other clinicopathological parameters (such as age, histological type, nodal status and tumor size, etc. ) using SPSS for Windows 10. 0.Results (1)The age of the patient is approximately normally distributed with slightly partial negative deviation. (2)The positive expression of P53 is diversed in different histological type (infiltrative lobular carcinoma, infiltrative ductal carcinoma, medullary carcinoma, mucus carcinoma and intraductal carcinoma) (P<0. 05), and it is the highest in medullary carcinoma. No direct relationship was found between P53 expression and the tumor size(P>0. 05), and nodal status(P>0. 05, P<0. 05), but there is a negative cor-relation(r=-0. 161, P<0. 05)between the positive expression of P53 and the positive expression of ER. (3)There is a distinction of P53 positive expression in different paraffin-embedded tissue (P < 0. 05). The positive expression of PR in paraffin-embedded tissue showed no correlation. There is also no correlation between the positive expression of ER, PR and the age(P>0. 05) , tumor size(P>0. 05) , and nodal status(P>0. 05). The positive ratings of ER and PR are of great consistency.Conclusion P53 gene is an important oncogene which has intensive relation with thedevelopment of cancer in human beings. Abnormal expression of P53 is diversed in different types of paraffin-embedded tissue. There is a negative correlation between the positiverating of P53 and that of ER. No direct relationship was found between P53 expression and the age, tumor size, and nodal status. P53-positive is an important indicator for clinical practice, however, further exploration is necessary for considering it to be an indicator for prognosis of patients with breast cancer.