Clinical Research On Shenan Chongji Treating Primary Nephrotic Syndrome With Deficiency Of Spleen-Yang And Kidney-Yang

Objective: To observe the effect of Shenanchongji (SACJ) in treating primary nephrotic syndrome (PNS) of the type of deficiency of spleen-yang and kidney-yang (DSK), and to explore its therapeutic mechanism.Methods: Based on the cause and mechanism of PNS, 90 patients with PNSDSK were divided randomly into SACJ group (30 cases), prednisone group (30 cases), SACJ and prednisone group (30 cases), and various indices observed and compared before and after treatment.Results: There were no significante difference among SACJ group, prednisone group and SACJ and prednisone group(p>0.05); SACJ nourishing the spleen and kidney significantly relieved the symptoms such as edema, pale complexion, intolerance of cold, weak and cold loins, anorexia, loose stool and lassitude. SACJ improved the renal functions, adjusted blood-lipids(TG,CHO,LDL-C,HDL-C), decreased urinary protein and increased plasma albumin. SACJ improved hemorheology including Bv, Pv and Rai. SACJ improved immunological IgG . There were no adverse reactions in SACJ clinical application.Conclusions: The effect of SACJ on PNS(DSK) is certain. The functional mechanisms include decreaseing urinary protein and blood-lipids, increasing plasma albumin, adjusting immunity and improving microcirculation and renal function. There are no adverse reactions in clinical application of SACJ. SACJ is effective and less adverse for PNS(DSK)...