Changes Of Coagulative And Fibrinolytic Parameters In Coronary Heart Disease

Coronary atherosclerosis , a disease of the coronary arteries, due to vascular occlusion and myocardial ischemia , then lead to Coronary Heart Disease (CHD). It is now clear that CHD is not simply an inevitable degenerative consequence of ageing , but rather a chronic condition that can be converted into an acute clinical event by plaque rupture and thrombosis .Many of the protien involved in coagulation and fibrinolysis that might contribute to a thrombotic tendency are related to the development of coronary artery disease.Objective: To explore the alterations of coagulative and fibrinolytic parameters with coronary heart disease for elucidate the mechanism of CHD and its clinical significance .Method: A series of hemostatic and fibrinolytic parameters were measured among 58 cases of CHD using ELISA and one-stage clotting assay , including coagulation factor V (FV) . coagulation factor VIII (F VIII ) , fibrinogen(Fg) , tissue-type plasminogen activator(t-PA) and plasminogen activator inhibitor-1(PAI-1).Results: The plasma level of FV , FVIII, Fg, PAI-1, PAI-1/ t-PA were elevated significantly in patients with AMI and UAP than in controls , and Fg, PAI-1 were higher in patients with AMI than with USP(P<0. 01). Plasma t-PA antigen was not dicreased inpatients with AMI and USP. Plasma FV and FVIII activity were not different significantly in patients with AMI and UAP. Difference of parameters between male and female was not found.Conclusion: It suggests that the alteration of coagulative and fibrinolytic systems play an important role in the pathogenesis, clinical classification and prognosis of CHD.