| Objective The insulin-like growth factors (IGF-I and IGF-II) have been implicated in regulating fetal growth and development. The aim of this study is to analyse the correlation between insulin-like growth factor I, II and growth parameter to determine which IGF is more important in regulating fetal growth and development. Methods Venous cord blood was obtained from 58 term newborns immediately after birth which were divided into three distinct groups (SGA, AGA, LGA) based upon their relationships of gestational age and birth weight. Birth weight(BW), length(L), and placental weight(PW) were recorded for each neonate. A specific radioimmunoassay was applied for the measurement of IGF-I and IGF-II. Simple regression and multiple regression were used to assess the relationship between IGF-I IGF-II and parameters. Results IGF-I concentrations in cord serum were 30~105ng/ml. The median of SGA, AGA. LGA was 40.45± 8.50ng/ml, 53.96 ± 10.2lng/ml, 68.95±14.08ng/ml respectively. IGF-I concentrations in AGA were higher than those in SGA(p<0.001), in LGA were higher than those in AGA(p<0.001). IGF-II concentrations were 264~520ng/ml. The median of SGA. AGA. LGA was 352.27±53.44ng/ml, 381.46 ±55.15ng/ml, 435.95±66.20ng/ml. IGF-II concentrations in LGA higher than those in AGA and SGA(P<0.05). No significant difference between SGA and AGA. IGF-I levels correlated significantly with BW(r=0.666, p<0.001), PI (r=0.553, p<0.001), PW (=0.543, p<0.001) .IGF-II levels correlated significantly with BW(r=0.406, p=0.002), PI (r=0.372, p=0.005) , not correlated with PW. According to multiple regression analysis , birth weight were onlydependent upon PI , length and IGF-I, whereas PW, gestational age and IGF-II did not contribute to the variance of birth weight. Conclusion Insulin-like growth factor I and II are all related to fetal growth and weight gain , and IGF-I correlates best with birth weight. These data suggest that IGF-I play a main role in the regulation of late growth and development. |
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