| er. In the study of other tumors, such as cervical cancer, ovary cancer, colon cancer, head and neck cancer, low or no expression of nm-23 is linked to poor prognosis. Likely, Yasuhiko ohta tested the primary cancer and lung hilar and mediastinal lymph node tissue, finding that nm-23 in primary tumor tissue is negatively related with lymph node micrometastasis and low nm-23 expression is significantly related with micrometastasis of bone marrow. But there are many contrary conclusion. So nm-23 is more than a non metastasis gene, and its function has tissue and time specificity. There are various kind of expression of nm-23 in various stage of tumor progression and various human cancer. The regulation mechanism of nm-23 gene expression is also very complicated, which is unclear now. expression of nm-23 is affected by many factors, such as other tumor related gene, protein molecule, hormone, receptor, etc. Some negatively regulate , and others, positively. In addition, the changing forms of nm-23 are also different, such as allele gene deletion, microsatellite instability, gene modification manner. All of these indicate that regulation of nm-23 gene for tumor progression process is complicated. It needs more study to make it clear whether nm-23 can promote or inhibit tumor progression.ObjectiveTo detect the expression of nm-23 in non small cell lung cancer by immuno-histochemistry, find the clinicalpathological factors that affect its expression, and to know the function of nm-23 on non small cell lung cancer, to direct monitoring disease and prognosis analysis.Methods1. To detect nm-23 gene expression product by IH SP in non small cell lung cancer.2. To find the clinicapathological factors affecting nm-23 expression by Lo-gistic regression analysis.ResultsOf the 82 patients, 49 showed positive expression of nm-23 in non small cell lung cancer, the positive rate is 59.76%. 1. Logistic univarite analysis:1) the positive rate of nm-23 gene expression of male patients is 54. 72% , while the female is 68,97% , there is no significant difference between these two groups(P= 0.208)2) the positive rate of nm-23 gene expression of patients aging less than 60 years old is 59.32% , while those more than 60 years old is 60.87% , there is no significant difference between these two groups (P =0.898).3) the positive rate of nm-23 gene expression of patients with lymph node metastasis is 6.50% , while patients without lymph node metastasis is 92.00% , there is significant difference between these two groups (P =0.000).4 ) the positive rate of nm-23 gene expression of patients of clinical I stage is 93.62% , while patients of LJ stage and DI stage is 21,74% , there is significant difference between these two groups( P =0.000).5 ) the positive rate of nm-23 gene expression of patients with tumor diameter less than 2 cm, is 65.22% , while those with tumor diameter more than 2 cm m is 57.63% , there is no significant difference between these two groups( P = 0.529).6) the positive rate of nm-23 gene expression of patients with central location is 35.48% , while patients peripheral location is 92.00% , there is significant difference between these two groups (P =0.000).7) the positive rate of nm-23 gene expression of good differentiation cancer is 95.35% , while moderate and poor is 20.51% , there is significant difference between these two groups ( P = 0.000).8 ) the positive rate of nm-23 gene expression of squmaous cell carcinoma is 77. 78% , while adenocarcinoma is 22.73% , and other types is 33.33% there is significant difference between squamous cell and adenocarcinoma and other kinds of non small cell lung cancer(P =0.000).2. Logistic multivariable analysis;It showed that expression of nm-23 is related with lymph node metastasis, tumor staging, tumor differentiation. There is a high positive rate of nm-23 expression in patients with early stage, negative lymph node metastasis and good differentiation(P = 0. 045^0. 03UO. 033). OR value is 12. 080, 0. 199, 0. 045, respectively.3. Analysis of co... |
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