| Background Because of its function of dispersion and regulating of Qi movement, Liver plays an important role in the process of life activity. Once lost the function, Liver-Qi will be stagnated and influence all organs. A clinical investigation discovered that liver ailment account for 36.56% of the five Zang-organs' Pathogenesis. Liver-Qi Stagnation Syndrome and its combining syndrome stay at first, account for 41.9% of liver ailment, so Liver-Qi Stagnation is the basic Pathological changes and the core of liver ailment. The incidence and recurrence rate is high in stomach ailment that caused by Liver-Qi Stagnation in clinic, therefore, it's very important to study the Pathological mechanism of Liver-Qi Stagnation affecting the stomach deeply.Objective Based on extensive collections and analynizing a great deal of medical documents, this paper systemic cleared up the TCM's recognation, physiological foundation, pathological mechanism and treatment of Liver-Qi Stagnation affecting the stomach. Moreover, integrating with modern medical knowledge and through animal experiment, this paper reveal the pathophysiological foundations of Liver-Qi Stagnation affecting the stomach will help to direct the clinical treatment.Materials and methods 60 healthy Wistar rats were divided into 3 groups randomly, male and female account for 50% respectively: blank group(G1), model group(G2) and resumed group(G3). The model were reproduced by "bind method". G3 were fed with herbal soup, G1 and G2 were fed with Saline in same dose. 14 days later, observed the naked eye changes and the pathologic histology changes of gastric mucosa, and determined the concentration of free mucus, PGE2 in gastric juice so as the concentration of SOD, MDA and NO in gastric mucosa homogenate. Then analyzed the meaning of the changes of all indexes.Result1, The pathomorphology of G2's gastric mucosa appeared inflammatory changes, well the others have no significant changes.2, The free mucus of G2 obviously lower than G1's (P<0.01) and G3's (P<0.05) . G3's also lower than G1's, though there is no statistical significance (P>0.05).3, The rank of the PGE2 level in every rats'gastric juice was G20.05).4, SOD level in G2's homogenate of gastric mucosa obveriously lower than G1's (P< 0.01 )and G3's(P < 0.05). And MDA level obveriously higher than G1's(P < 0.01 ).The detection of SOD and MDA in G3 has no significant difference to G1's(P>0.05).5, NO level in the G2's homogenate of gastric mucosa obveriously lower than G1's (P < 0.01) and G3's (P<0.05) . G3's has no significant difference to G]'s(P>.05).Conclusion1, Liver-Qi Stagnation can lead to the inflammatory pathological changes in gastric mucosa.2, The concentration of free mucus, PGE2 in gastric juice and the abnormal changes of NO, SOD, MDA in gastric mucosa were one of the main pathophysiological foundations of the gastric mucosa inflammation caused by Liver-Qi Stagnation.3, The herbs of relieving the depressed liver can prevent and treat stomach ailment that caused by Liver-Qi Stagnation, the inner mechanism was it could regulated the concentration of free mucus, PGE2 in gastric juice and the level of NO, SOD, MDA in gastric mucosa , and it could reinforce the protective function of gastric mucosa. |
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