An Experimental Research On The Effect Of Promoting BloodCirculation To Remove Blood Stasis On Endometrial Uterine Blood Rheology And Relative Factors Of Wearing Cu-IUD Rabbits

Objective: Intrauterine device (IUD) is one of effective contraceptive methods for the women of childbearing age in China which are widely used. Inserting IUD can lead to cyclic menstrual bleeding that is excessive in amount or duration and intermenstrual bleeding. That is endometrorrhagia which is caused by IUD-wearing. It is the main reason which decrease the using rate of IUD. This experimental objective is to explore the mechanism of Radix Notoginseng and Radix Rubiae complex prescription based on promoting blood circulation to remove blood stasis for treating endometrorrhagia caused by Cu-IUD, to study the effect of SQ complex prescription on endometrial biochemical medium and blood rheology of rabbits wearing Cu-IUD, to dicuss the mechanism of action in SQ complex prescription, and to provide experimental foundation for the therapy of this disease.Methods: The rabbits were randomly devided into seven groups: normal group, sham-operation group, model group, indomethacin group, high dosage group of SQ complex precription , middle dosage group of SQ complex precription , low dosage group of SQ complex precription . Cu-IUD-Wearing rabbit models were established. In contrast with indomethacin, weinvestigated the effects of SQ complexe prescription on endometrial several aspects including as prostacychine ,thromborane A2 ,plaminogen activator and blood rheology of Cu-IUD-wearing rabbits.Results:1. SQ complex prescription decreased the contents of prostacycline(PGl2), and raised thromorance A2 and regulated the ratio of PGI2 to TXA2.2. SQ complex prescription decreased the contends of tissue plasminogenactivator(t-PA).3. SQ complex prescription decreased the demsity of hemotocnit,totalblood viscosity (low,middle, high) and seram viscosity,and improved blood rheology.Conclusion: All mentioned above indicate that the method can regulate the release of biochemical medium in the uterine tissues and improve blood rheology, So endometrorrhagia caused by lUD-wearing can be prevented and cured by the method effectively.