Study On Relationship Between C-reactive Protein, Interleukin-6, Tumor Necrosis Factor-alpha And Obesity In Young Woman Adults

Objective: To study the relationship between inflammation and obesity as well as observe the effects of weight loss on inflammation and lipid metabolism among the obese women of 17-31 years old. Subjects and Methods: Adopting cross-sectional, control study and premeasure-postmeasure design, 45 women aged from 17 to 31, met with the inclusive criteria were under an multidisciplinary intervention consisting of behavioral and nutritional counseling, diet and aerobic exercises for 6 successive weeks and divided into overweight-obesity group(OB group, including 29 subjects aged from 17 ~ 31 years) and nonobesity group(NOB group, including 16 subjects aged from 18-29 years) according to the diagnosed criteria on obesi ty of WHO. Their anthropometric variables including body mass index (BMI), waist circumference (WC), body fat contents (percentage) and serum levels of two proinflammatory cytokines, that is interleukin-6(IL-6) and tumor necrosis factor-alpha (TNF-a ), acute inflammatory reactive markers-C-reactive protein(CRP) as well as triglyceride(TG), total cholesterol(TC) and high density lipoprotein-cholesterol (HDL-c) were measured, calculated and determined, then compared between and within the two groups before and after weight loss. Results: At baseline, there were significant differences on body weight, BMI, WC , FAT%(P<0.001, respectively)and serum content of HDL-c(P<0. 05), while no differences on serum levels of TNF-a, IL-6, CRP, TG and TC(all P>0. 05) between OB group and NOB group. Serum levels of TNF-a , IL-6 and CRP were positively correlated with BMI, WC and FAT% in OBgroup by Spearman rank correlation analysis and so did among the blood concentrations of TNF-a , IL-6 and CRP(all P<0. 05). After six weeks of intervention on weight loss, body weight, WC(P<0. 001), and HDL-c(P<0. 05) were greatly changed in both groups. Within OB group, BMI, FAT%, serum TNF-a , TC(all P<0. 001)and CRP(P<0. 01)decreased greatly and through Pearson linear correlation analysis, positive correlation were found between the decreased serum level of CRP and the changed BMT and FAT%(P<0. 05) as well as between the reduced serum TNF-a and WC(P<0. 05), while the changed anthropometric variables were significant negatively related to the increased serum level of HDL-c(P<0. 05 or P<0. 01). The left observed indices in both groups didn't changed greatly by weight loss (all P>0.05). Conclusions: The close relationship between body weight, BMI, WC, FAT% and the three serum inflammatory markers suggests that an extent of chronic inflammatory stress might exist in .17~31-year-old obese women, which could be ameliorated through an short-term intervention on weight loss including aerobic exercises. Weight loss also reduce total body fat and change local(visceral) fat distribution so as to alleviate central obesity and have beneficial effect on lipid metabolism.