Analyzing The Effect On Inhaling Magnesium Sulfate To Treat Infants With Bronchiolitis

Objective: To evaluate the therapeutic effects and safety on inhalation of Magnesium Sulfate in the treatment of acute bronchiolitis in infants; to search for the best therapy method when acute wheeze attack. Methods: Total ninety infants with bronchiolitis hospitalized in department of pediatrics were randomly divided into 3 groups and respectively assigned to receive either 25% magnesium sulfate infusion (0.1~0.2ml/kg/time) inhalation through a pump nebulizer or 25% magnesium sulfate intravenous injection (0.1~0.2ml/kg/time) or normal saline inhalation on the base of same comprehensive treatment. To observe change of blood gas,Dobson score,clinical symptoms and signs of three groups. Results: (1) 24 hours later, PaO2. SaO2 and PaCO2 level in magnesium sulfate inhalation group were better than that of pre-treatment (P<0.01);That of intravenous injection group and control group were not significantly changed (P>0.05). (2)Magnesium sulfate inhalation group and intravenous injection group were superior to control group in terms of the improvement of clinical Dobson scores, clinical symptoms, signs continuous time and hospital days (P<0.01); Magnesium sulfate inhalation group were also superior to intravenous injection group.(3)After treatment, Clinical total efficacyrate in magnesium sulfate inhalation group (93.33%) was obviously superior to intravenous injection group (73.33%) (x2=3.92, P0.05) and that of control group (16.67%)(x2=14.8, P<0.001); clinical total efficacy rate of magnesium sulfate intravenous injection group was also obviously superior to that of control group (x2 = 9.27, P<0.05). Conclusion: Inhalation treatment of magnesium sulfate by nebulizer to infants with bronchiolitis can effecti-vely relieve wheeze, improve lack of oxygen, advance assimilation of pulmonary rale and recoveration of pulmonary function; The therapeutic effects of inhalation by nebulizer were more obviously and side effects were less than magnesium sulfate intravenous injection group. Therefore inhalation treatment of magnesium sulfate was a safer, more effective, economic and convenient therapy method especially for infants with bronchiolitis.