The Study On The Treatment Methood Of TCM Of Accumulation Of Phlegm-heat In Lung Syndrome Of Children's Virus Pneumonia

ObjectiveTo study on the treatment of accumulation of phlegm-heat in lung syndrome of children's virus pneumonia with Qing Fei oral liquid, controlled by ribavirin injection. To assess the efficacy and safty of Qing Fei oral liquid and to discover that the therapy of clearing lung to resolve phlegm and removing toxical material in treating accumulation of phlegm-heat syndrome of children's virus pneumonia is scientific. MethodsAccording to the rule of stratified randomization, equal control, blind, multicent clinical study, in Nanjing Military Area Central Hospital, 90 cases had been carefully chosen as study subjects according to the western medicine s diagnostic criterion of children's virus pneumonia and the TCM diagnostic criterion of accumulation of phlegm-heat syndrome of children's virus pneumonia. According to the rule of randomization, all subjects were divided into two groups, test group(group I ) and controlled group(group II ).The ration was 2:1.The randomized code form was also created by computer. The unified lists about cases were filled to study the difference between the status before cases being cured and after cases being cured.Group I was given Qingfei oral liquid, which has the function to resolve phlegm and removing toxical material, and infusion liquid without any antivirus and antibiotics. Group II was infusedribavirin injection and oral placebo. The observing course was 10 days.ResultsThere are, prior to the study, no significant differences between the two groups general information, the leading symptoms and signs, secondary symptoms and signs and physical examinations and laboratory tests except for the sex and texture of tongue. It means that the two groups can be compared. 58 cases of test group and 29 cases of controlled group accorded with the project. The cured, significant effective, improved and ineffective cases of group I were 50, 5, 3, 0. The cured, significant effective, improved and ineffective cases of group II were 15, 14, 0, 0. With rank sum test ,it showed that Z=4.63 , P< 0.0001 .The effect of test group was much better than of the controlled group. Compared with the controlled group, the indexes of test group of the symptoms, signs, physical examinations and laboratory tests including cough, flaring of nares, auscultation on lung, cyanopathy, urine, limb, X-ray of chest were much better. There are no significant differences between the two groups in treating fever, sputum, short breath, aversion to cold, feces, vitality, sweating, thirst, nausea, blood routine test and the virus test of the secretion of nose and throat. The study of clinical safety showed that Qingfei oral liquid had not any harms and side effects on important organs.Conclusions:T therapy of clearing lung to resolve phlegm and removing toxical material herapy of clearing lung to resolve phlegm and removing toxical material is effective in treating accumulation of phlegm-heat syndrome of children's virus pneumonia.