| Background and ObjectiveOxidative stress has been attached importance on Acute coronary syndrome in its pathogenesis in recent years. 8-iso-prostaglandin F2 (8-iso-PG F2) is a new product of isoprostanes (discovered in recent years) produced by oxidative injury to bio-membrane lipids. 8-iso-PG F2a is the main component of the isoprostanes, widely exits plasma and tissue. It is a sensitive and specific indicator of oxidative stress. Studies in recent years have demonstrated that 8-iso-PG F2 is greatly elevated in the cardiovascular diseases such as: Coronary heart disease. In order to investigate the oxidative stress situation in the early stage of ACS, we analyzed the plasma level of 8-iso-PG Fia and using atorvastatin to treat the ACS patients in our study . Through analyzing the plasma level of 8-iso-PG Faa and the effect of atorvastatin on it, we can know the influence of atorvastatin on the oxidative injury in the ACS and we may evaluate the merit of early statin treatment in the ACS patients .MethodsWe selected the ACS in-patients in the department of cardiology from the time 2003-3 to 2003-10. All patients didn't use any anti-lipid or any anti-prostaglandinmedicines before the study within 2 weeks. The criteria of ACS were according to the ACC/AHA Guidelines for ACS (2000). 60 patients were enrolled. All these patients were divided into 2 groups: (1) UA group (n=36), (2) AMI group (n=24). We also selected 16 healthy people as (3) control group (n=16). All patients were examined to exclude valvular disease, cancer, severe hepatic-renal disease, thyroid dysfunction, self-immune disease. Also these ACS patients were stratified by randomized, single-blind, contrastive assigned to A group (usual therapy for 1 week, n=30), B group (Atorvastatin 10 mg/d for 1 week). The plasma levels of 8-iso-PG F 2, TXB2, 6-Keto- PGF.a and serum TC, TG, HDL-C, LDL-C were detected before and after treatment. The plasma levels of 8-iso-PGF2 were measured with enzyme linked immunosorbent assay (ELISA), and the plasma levels of TXBa, 6-Keto- PGFia were analyzed by radioinmmunoassay (RIA). Results (1) At baseline, compared with control group, the plasma levels of 8-iso-PGFzawere significantly higher in UA and AMI group. Levels of 8-iso-PGF2a in the control, UA and AMI group were 82.56+10.88, 599.25 + 160.20, 1171 188.75(pg/ml) respectively. The plasma levels of TXBj in the UA and AMI group were obviously higher than the control group. Levels of TXBi in three group were as follows: the control group 92.81+20.36 (pg/ml) , the UA group 185.83 + 38.21(pg/ml), the AMI group 324.00 40.78(pg/ml).The levels of 6-Keto- PGFia were obviously decreased in the UA and AMI group compared with the control group. Levels of 6-Keto- PGFia in the control, UA and AMI group respectively were: 104.63 + 13.29, 77.83 + 7.2K 53.87 + 6.35 (pg/ml) . The levels of serum TC,TG and LDL-C in the UA group were much increased compared with the control group, AMI group. But there was no statistical difference between the control and AMI group; furthermore the levels of TC in the AMI group were lower than the control group. The serum levels of HDL-C in the UA and AMI group were much lower than the control group, and the AMI group was the lowest. BMI and WHR in the UA and AMI group were elevated distinctly compared to the control group; the AMI group was higher than the UA group. The ages in all groups were no statisticalsignificance.(2) In the basic conditions, the correlation analysis between these indices indicated that: the plasma concentration of 8-iso-PGF2 was positively correlated with TXB2, BMI and WHR strongly, with LDL-C slightly, negatively with 6-Keto-PGFia and HDL-C obviously, no correlation with TC, TG and age.(3) The changes of S^iso-PGFza and other indices after atorvastatin therapy: the plasma concentration of 8-iso-PGF2 and TXB2 were greatly decreased compared with baseline, respectively decreasing 42.23%, 36.63%; the plasma levels of 6-Keto- PGF were largely increased compared with baseline, increasing 43.23%. TC, TG, LDL-C... |
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