Influence Of Early Intervention With Atorvastatin On The Level Of Serum Inflammatory Factors In Patients With Acute Coronary Syndrome

Objective:To observe the anti-inflammatory influence of early intervention with atorvastatin on serum inflammatory cytokines IL-6,MMP-9 and Hs-CRP levels in patients with acute coronary syndrome.Methods:50 patients diagnosed ACS by clinical symptoms,ECG and myocardiac enzymes,including 28 patients with acute myocardial infarction(AMI)(16 male and 12 female,average age 58.82±11.67),22 patients with UAP(12 male and 10 female,average age 58.82±11.67) were studied.20 healthy control were choosed from our local physical examination center(12 male and 8 female,average age 57±8.8).All patients were treated with atorvastatin(20mg/d,4 weeks).The concentration of serum inflammatory cytokines IL-6,MMP-9,hs-CRP and the level of blood lipids were measured before treated and one week,two week and four week- treatment.Results:The level of blood lipids and plasma inflammatory cytokines IL-6,MMP-9 and hs-CRP of all patients before atorvastatin treatment was higher compared with the control group(p＜0.05).After treated with atorvastatin 20mg/d,the concentration of blood lipids,IL-6,MMP-9 and hs-CRP of all patients has prominent discrepancy compared with the previous(p＜0.05).The decrease of plasma inflammatory cytokines concentration had no relationship with blood lipids changes pretreatment and posttreatment(p＞0.05).The concentration of plasma inflammatory cytokines IL-6,MMP-9 and hs-CRP in subgroups were not significant different both pretreatment and posttreatment(p＞0.05).Conclusions:Early use of atorvastatin can decrease the concentration of plasma inflammatory cytokines IL-6,MMP-9 and hs-CRP in ACS patients. Early statins treatment could suppress inflammation status,stabilize atherosclerotic plaques and prevent plaques from rupture.And the decrease of plasma inflammatory cytokines had no relationship with blood lipids changes.