The Modulatory Role Of Multiplex Oolong Tea On Lipid Metabolism In Female SD Rats With Hyperlipidemia

ObjectiveThis study was conducted to explore the hypolipid role of multiplex oolong tea (MOT) on lipid metabolism in female SD rats with hyperlipidemia, and to gather the information for utilizing the multiplex oolong tea as functional food.Method1. The making of multiplex oolong tea is based on Chinese herbal medicine screening and counseling from specialist.2. 48 female SD rats of 2 months old were divided randomly into 6 groups by body weights: (I) control group, (II) hyerlipidemia model group, (III) MOT of high dosage, (IV) MOT of middle dosage, (V) MOT of high dosage and (VI) oolong tea group. Rats in group II-VI were fed with fat-enriched diet for 64 days. Lipid profile was checked to make sure that the diet-induced hyperlipidemia was formulated. 3. Body weight, serum total cholesterol (TC), triglyceride (TG), LDL-C, HDL-C, liver cholesterol (LC), liver triglyceride (LG), hepatic lipase and lipoprotein lipase activity, feces excretion and fecal fatty content were examined to evaluate and probe the modulatory role of multiplex oolong tea.Result1. TC, TG, LDL-C level were elevated in hyperlipidemia model group compared with those in control group (p<0.05). However, the HDL-C concentration is significantly decreased in model group compared with that in control group (p<0.05 ). 2. Compared with hyerlipidemia model, serum TC and TG of IV and V groups were significantly reduced (p<0.05). TG in group VI is lower than that of model group (p<0.05). TC and LDL-C level in MOT of middle dosage is significantly reduced than those treated with oolong tea (p<0.05). 3. LC content of group IV and V were decreased compared with that model group (p<0.05), however, the LG level in group III-VI didn't differ with that of model group (p>0.05).4. HL and LPL activity of group V were reduced compared with model group (p<0.05). Conclusion 1. SD rats fet with diet rich in cholesterol, lard and bile acid salt for 64 days will formulate hyperlipidemia.2. MOT can lowing TC and TG, elevating HDL-C. The effect of lowing TC and LDL-C of MOT is better than that of oolong tea.3. MOT may modulate the lipid level through increasing feces excretion and elevating fecal content as well as depressing HL and LPL activity.