The Relation Between Serum IGF-1,NO Levels Of Umbilical Blood And Placental Pathologic Changes And Brain Injury In Premature Infant.

Objective:To study the relation between serum IGF-1,NO levels of umbilical blood and placental pathologic changes and brain injury in premature infant. Methods:The concentration of umbilical serum IGF-1,NO were determined from JAN 2003 to JAN 2004.Placental pathologic changes were observed by light microscopy. Meanwhile,premature infants′outcomes were invested. Results:Brain injury occurred in 10 term premature infant; In comparison with normal controls,IGF-1 levels of premature and hypoxic groups in umbilical blood decreased and NO levels increased.Difference in IGF-1,NO levels between brain injury group and without brain injury group was significant;There was a negative relationship between the levels of IGF-1 and NO in all newborn infants and premature group,a positive relationship in hypoxic group,no relationship in normal controls;The rate of placental pathologic changes in premature group was higher than normal controls,but difference in the rate between brain injury group and without brain injury group was not significant;Logistic regression showed that IGF-1 was a protective factor and NO was a dangerous factor;According to ROC curve,we could obtain the cut off points that might judge whether brain injury occurred or not,which were IGF-1 was 21.92ng/ml,NO was 95.18μmol/L. Conclusion:Serum low IGF-1,high NO levels of umbilical blood in premature infant are associated with brain injury.