Expression And Significance Of BRCA1 And P53 In Breast Cancer Of Korean And Han Women In Yanbian

Objective: To investigate the significance of the expression of BRCA1 and P53 in breast cancer of Korean and Han women in Yanbian to offer more important molecular biological data of human carcinogenesis. Methods: The expressions of BRCA1 and p53 protein in 62 cases of breast cancer tissues, 14 cases of breast fibroadenoma tissues were examined by immunohistochemical SP method. Results: 1. The positive expression rate of BRCA1 (59.7%) was significantly lower than thatin breast fibroadenoma (92.9%) (p<0.05). 2. The expression of BRCA1 was reversely correlated with histological grade. The lower rate of the expression of BRCA1 was found in those patients with higher histological grade (p<0.05). But it was not correlated with age of onset, histological type, TNM stage and ER&PR status (p>0.05). The level of BRCA1 expression decreased with pathological gradeincreasing, and BRCA1 expression also reduced in breast cancers with lymph node metastasis increasing. 3. The positive expression rate of BRCA1 in the group (66.7%)that has family histories was higher than that in the group (57.6%) that has notfamily histories. But there was no significant difference between them (p>0.05). 4. The positive expression rate of P53 in breast cancer (38.7%) was higher than that in breast fibroadenoma (0) (p<0.05). This positive expression rate in stage III ofbreast cancer was higher than that in Stage I (p<0.01) and was also higher than that in Stage II(p<0.05). The expression of P53 was not correlated with histological type, histological grade, lymph node status and ER and PR status(p>0.05). S.The positiveexpression rate of BRCAI decreased with the level of P53 expression increasing. But there were not significant correlations between them ( r=-0.074 p=0.570 ) .6.Although the expression of BRCAI and P53 in breast cancers of Korean patients was different from that of Han patients, no significant difference was found betweenthem (p>0.05) . Conclusions: 1. The results suggest that the reduction of BRCAIexpression and the increasing of P53 expression play an important role in the occurrence and development of breast cancer. These findings also suggest that the detection of multiple factors is more valuable than that of single factor. Multiple factors are helpful for pathological diagnosis, prognosis and treatment. 2. BRCAI expression is not significantly correlated with P53 expression. 3. The expression of BRCAI and P53 of Korean patients is not significantly different from that of Hanpatients in Yanbian.