The Hepatic Perfusion Change In Cirrhosis Assessed By 16 Slices Spiral-CT

Purpose: To measure hepatic perfusion parameters with 16 slices spiral -CT and to study these parameters'change in different severity of liver cirrhosis. Material and Method: Dynamic contrast-enhanced single-location sequences CT scans of the liver were obtained in 68 individuals who included 29 control subjects ,22 patients with compensated cirrhosis and 17 patients with decompensated cirrhosis proven by clinical. Liver perfusion parameters such as hepatic blood flow (BF),blood volume (BV),mean transit time (MTT),permeability surface area product (PS) and hepatic arterial fraction (HAF) were calculated. Results: BF in control patients group, compensated cirrhosis group anddecompensated cirrhosis group didn't change obviously (P=0.470). Comparing to control group, The other perfusion parameters were't significantly altered in compensated cirrhosis group but in decompensated cirrhosis group: PS (control patients group 18.945±7.2347 ml/100ml/min, decompensated cirrhosis group 27.806±7.4730ml/100ml/min,P=0.006) and HAF (control patients group 0.17934±0.090936, decompensated cirrhosis group 0.28735±0.130654,P= 0.022) raised clearly. BV (control patients group 14.3407±5.54649ml/100ml, decompensated cirrhosis group 9.1871±2.15263 ml/100ml,P= 0.000) and MTT (control patients group 15.613±4.1746s, decompensated cirrhosis group 11.721±4.5861s,P=0.006) decreased remarkably. Conclusion: The severity of liver cirrhosis can be assessed by CT hepatic perfusion technique.