Experimental Study On Treatment Of Osteoporotic Verterbral Compression Fracture With The Different Injectable Material In Vertebroplasty

Objective: To provide the theories for the clinical application by development observing biomechanics and pathology changes after vertebroplasty with the different filling materials in experimental osteoporotic rabbit. Methods: 70 New Zealand pure breed female rabbits of 5 months old was divide into five groups(A,B,C,D,E), and each group had 14 rabbits. A group was normal matched control and osteoporotic model were established by ovariectomy from B to E group. Implanted Polymethylmethacrylate (PMMA) into the vertebral body of C group and Calcium phosphate cement (CPC) into D group and CPC/BMP (Bone morphogenic protein) into E group. B group was the model matched control. When at 0, 8 and 16 weeks old, the vertebral bodies implanted were tested by X ray and axial compressive testing and pathology observe.Results: (1) Bone cement leaked into vertebral canal in case of C group after operation and the density of vertebral bodies were high than others by X ray. (2) At once after operation, the ultimate strength of vertebral bodies with implanted PMMA was higher than that others (p<0.001) and A group was second place (B group p<0.001, D group p<0.01, E group p<0.01). There were no significant differences in B, D and E groups (p>0.05). After 8 weeks, the stiffness of A group became low, but have no to show the differences compare to before ( P>0.05). The stiffness of D and E group became strong ( p<0.01). There was no significant differences in A and E groups (p > 0.05 ) and significant differences in A and D groups (p<0.01). When it came to 16 weeks, the stiffness of A group became more lower ( p<0.01) and of D and E group became more stronger (p<0.01). There was no significant differences in A, C, D and E groups (p>0.05). At the last was B group, There was very significant differences between B and other groups ( p<0.01). (3) After 16 weeks, bone trabeculae was clear and arranged orderly in A group and small beam and mess in B group. There was large quantity bone cement and no necrohistology in C group. There...