Effects Of Laparoscopic Hepatectomy On Stress Response And Immunologic Function In Patients

Objective: To compare prospectively effects of laparoscopic hepatectomy (LH) and open hepatectomy(OH) on stress response and immunologic function of patients, reveal the regularity of physiological and pathological change in human body following LH, evaluate patients' traumatic reaction after LH, analyze the factors related to the minimal invasion from LH, and explore the mechanism of minimal invasion from LH.Methods: 40 patients with hepatectomy were divided into LH and OH group randomly. There were 20 cases in each group respectively, and total 7 cases were eliminated according to our protocol. Data of 16 LH and 17 OH were studied and analyzed. All operations were performed by the same group surgeons in general anesthesia.Data of patients were recorded, including length of incision, surgical and anesthetic duration, intraoperative blood loss; postoperative eating date, dosage of painkiller, hospital stay, complication and body temperature. All patients' venous blood were sampled to measure liver function, stress markers (cortisol, blood glucose, CRP, IL-6, TNF, WBC, N) and immunologic markers (IgA, IgG, IgM, C3, C4) before operation, at operative endpoint, in the morning of the 1st, 2nd, 3rd day after operation.Measurement data were expressed as means+SD(x±x) and analyzed by t Test. Enumeration data were expressed as frequency(n) and analyzed by Fish's exact X~2. Results: Average length of incision in LH group was one fourth shorter than that...