Study Of The Relationship Between Phlegm-Blood Stasis Syndrome, Serum CD40 Ligand And Inflammation In Patients With Acute Coronary Syndrome

Objective Through a great amount documents retrospecting in this research, We found that, most of the studies about the reasons and mechanisms of the formation of CAD marked by phlegm-blood stasis syndrome, focus on the abnormity of lipoprotein and hemorheology, but few on immunity or inflammation. Pointing to the vacancy in the research of phlegm-blood stasis syndrome of ACS, we try to explore into the relationship among phlegm-blood stasis syndrome, serum CD40 ligand and inflammation mediums in patients with ACS. We also analyze the correlation of serum CD40L with some kinds of inflammation mediums and blood lipid. Methods 64 ACS patients were divided into phlegm-blood stasis group(35) and non-phlegm-blood stasis group(29) in accordance with the standard of the syndrome differentiation of TCM. 22 healthy people were in the control group. Measured serum CD40L by ELISA in the three groups and analyzed the variety rule of serum CD40L among the three groups. Detected the level of C-reactive protein (CRP), fibrinogen (FIB), interleukin-6(IL-6), tumor necrosis factor-alpha(TNF-a), D-Dimer(D-D) of the phlegm-blood stasis group and the non-phlegm-blood stasis group, in the meantime, analyzed the relationship between the phlegm-blood stasis syndrome of ACS and the inflammation mediums. The variety of the three kinds of blood lipid (TC, TG, LDL-C) between the phlegm-blood stasis group and the non-phlegm-blood stasis group were also studied.Results sCD40L level in the phlegm-blood stasis group and the non-phlegm-blood stasis group of ACS were both significantly higher than in the control group(P<0. OK P<0.05). sCD40L level in phlegm-blood stasis group was also significantly higher than in the non-phlegm-blood stasis...