Clinical Significance Of Plasma SCD40L Changes In Patients With Different Types Of Coronary Heart Diseases

Objective: To investigate the clinical significance of plasma levels of soluble CD40L(sCD40L)in patients with different types of coronary heart diseases,to explore the relationship between the concentration of sCD40L in plasma and the severity of coronary stenosis,and the correlation between it and TIMI risk score in ACS patients.Methods: Thirty normal subjects made up the control group and 90 patients,including 30 with stable angina pectoris(SA),30 with unstable angina pectoris(UA)and 30 with acute myocardial infarct(AMI)were enrolled in this study.NSTEMI and UA cases were separated into 2 groups by TIMI risk score.The blood samples were drawn from venous within 24 hours after hospitalization.The sCD40L levels in plasma were measured by ELISA.Results: The plasma levels of sCD40L in UA patients and AMI patients were higher compared with those with SA and those in control group(P<0.05),with no significant difference between AMI and UA and between SA and control group;Compared cases whose TIMI risk score?3 with those whose score ?2 show a much higher concentration of sCD40L(P<0.001),There is positive correlation between the TIMI risk score and the plasma levels of sCD40L(r=0.774,P<0.001).There was no correlation between the severity of coronary stenosis and the sCD40L values.Conclusion: The sCD40L values in the patients with AMI and UA are significantly higher than those in SA and contral groups,which may reflect the stability of coronary atherosclerotic plaque.The plasma levels of sCD40L were useful to estimate the risk of ACS patients.The plasma levels of sCD40L were decided by the stability of Plaque rather than the degree of coronary stenosis.