The Changes Of Serum Insulin,Glucagon,C-peptide, Blood Glucose And Their Clinical Significance After Acute Brain Injury

Objective: To study the relationship between the changes of serum insulin, glucagon, c-peptide, blood glucose and the severity and prognosis of brain injury in the patients with acute brain injury.Method: 112 brain-injured and 32 control subjects were selected according to the level of glycated protein in serum by GSP enzymatic assay. The levels of serum insulin, glucagon and c-peptide were detected by chemiluminescent immunoassay;then the level of blood glucose in the patients(GCS<12) (after brain injury) were examined by GOD-POD assay at post-injury of 1, 3,5,7,14 days respectively. All these results were statistical analyzed.Results: The levels of serum insulin, glucagon, c-peptide and blood glucose were significantly higher in the traumatic head-injured patients than those in the control group (P<0.05). The more serious the brain injury was, the more significant all these changes were and the poorer the neurologic outcome was. The blood glucose would decrease when the state of patients improved.Conclusions: The levels of serum insulin, glucagon, c-peptide and blood glucose after acute cerebral injury may be one of the indexes of acute...