Effect Of Salvia Miltiorrhiza Compound On Oxygen Metabolism Of Tissue During Cardiopulmonary Bypass In Children

Objective : To explore the tissue hypoxia and to explore whether salvia miltiorrhiza compound improved the tissue hypoxia during cardiopulmonary bypass(CPB) operations, through the change of plasma Lactate and tissue oxygen metabolism.Methods: Twenty children with congenital cardiac disease, below 10kg, were randomly assigned into one of two-groups. Salvia miltiorrhiza compound was infused to improve tissue.hypoxia in A group. B group was a control one. Arterial and mixed venous blood gas, and blood lactate lever were measured before operations, before CPB, after CPB30', rewarming 34℃, after CPB 1 -3' and ending operation.Results: After CPB, the plasma lactate level of both groups increased gradually, was the highest in rewarming 34℃, then slowly reduced. The change of lactate was significantly higher in CPB30', in rewarming 34℃, after CPB(1-3) and in ending operation than (p<0.01). The plasma Lactate level in treaded group was lower than that in control group in CPB30', in rewarming, there was significant change (p<0.05). The Ca-vO2 and ERO2 level of both groups was the highest in ending operation, The Ca-vO₂ level was significantly higher than that before operation in A group(p<0.05); and the ERO2 level in ending operation was significantly higher than that before operation in A group(p<0.01). In rewarming 34℃...