Clinical Application Of Positron Emission Tomography (PET) With ～(18)F-fluorodeoxyglucose (～(18)F-FDG) In Patients Of Central Nervous System Diseases

Background & AimsAs one of techniques of functional imaging in modern time, positron emission tomography ( PET) has particular mechanism of detection, favorable sensitivity and resolution, which give it a broad prospect of application in patients with central nervous system diseases.Intracranial tumors and epilepsy are two types of common diseases in central nervous system. According to finds of imaging, we can locate the foci and determine the nature of these diseases. The characteristics of energy metabolism in foci, especially glucose metabolism in foci, provide the feasibility for diagnosis of two these diseases with PET.After reviewing the other related studies of ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) PET on intracranial tumors and epilepsy, we made the retrospective analyses of our cases in order to evaluate the value of ¹⁸F-FDG PET on them.Section one The characteristics and significance of ¹⁸F-FDG PET imaging in intracranial tumorsObjectiveTo discuss the characteristics and significance of ¹⁸F-FDG PET imaging in intracranial tumors.Methods¹⁸F-FDG PET images of 24 cases, which consisted of gliomas, meningiomas, metastatic brain tumors, benign brain diseases and normal persons, were analyzed semiquantitatively and compared with each other.Results6 of 9 patients with gliomas had more (or equal) ¹⁸F-FDG uptake in foci than in normal gray matter; 2 patients with meningiomas both had less F-FDG uptake in foci than in normal white matter; 5 patients with metastatic brain tumors had the different (more or less) ' 8F-FDG uptake in foci than in normal gray matter; 2 of 4 patients with benign brain diseases had more l8F-FDG uptake in foci than in normal gray matter.ConclusionsTumors from brain parenchyma and meninges have different c haracteristics of ¹⁸F-FDG PET images, and the difference still remains between primary intracranial tumors and metastatic brain tumors.¹⁸F-FDG PET images can provide us with significant information about classification, grade, prognosis and response to the therapy in patients with intracranial tumors.Section two The clinical value of F-FDG PET cerebral imaging in focus localization of epilepsyObjectiveTo discuss the clinical value of ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) PET cerebral imaging in focus localization of patients with all kings of epilepsies. Methods 65 patients of epilepsies were studied with interictal ¹⁸F-FDG PET cerebral...