Study On Skull Slot Needling Adding To Drugs Effecting To Neural Function Healing And The Plasma Fibrinolysis System On Rehabilitation Of Cerebral Infarction Patients

Objective: To study the improvement of clinical neural function rehabilitation of cerebral infarction patients by the skull needling and its effect on the amount of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) in plasma.Method: According to the clinical diagnostic criterion of the cerebrovascular disease in the forth national academic discussion of cerebrovascular disease in Chengdu. Choosing 40 patients of cerebral infarction rehabilitation, whose ages is at 45~75 years old, and then they are divided into two groups by random, 20 cases were treated with the skull slot needling combined with medicines(Group A), another 20 cases were treated with the same medicines as Group A, such as modulation arteriotony to prophylaxis cerebrovascular spasm; anti-plaelet aggregation; improve brain circulation; etc(Group B). After one course of treatment, to observe and compare the amount of plasma t-PA and PAI-1 and the scores in clinical neural function of two groups of patients..Results:(1) Compared with normal level, plasma t-PA level decreased, PAI-1 increased and T/P decreased in patients of cerebral infarction rehabilitation.(2) In the routine medicine group(Group B), the significant decrease of the scores in clinical neural function (P<0.05) was observed, and the scores of clinical neural function in the skull slot needling group(Group A) decreases significantly, too (P<0.01) ,and lower than the routine medicine group(Group B). There was no significant change of plasma t-PA and PAI-1 in the routine medicines group(P>0.05), but they increase significantly in the skull slot needling group(P<0.01 ),and higher than that in medicine treating group (P<0.05).(3) The scores of clinical neural function is correlated with Plasma t-PA positively and PAI-1 negatively before and after the treatment.Conclusions:(1) It is suggested that there were function imbalance of plasma fibrinolysis system in patients of cerebral infarction rehabilitation.(2) Both the skull slot needling and medicine treatment can obviously improve the scores in clinical neural function; The therapeutic effect in skull slot needling combined with medicine treating group was superior to that in medicine treatment group.(3) The skull slot needling treatment can obviously improve the scores in clinical neural function, and prompt the up-building or opening of side circulation in brain tissue and the regeneration of new blood vessel .(4)The concentration of plasma t-PA and PAI-1 was likely related to rehabilitation of cerebral infarction patients and can reflect the degree of brain impairment in rehabilitation of cerebral infarction patients.