Expression And Significance Of VEGF, PD-ECGF And COX-2 In Laryngeal Squamous Cell Carcinoma

Objectives: To investigate the significance of vascular endothelial growth factor (VEGF ) ,platelet-derived growth factor ( PD-ECGF ) and cyclooxygenase-2 (COX-2) expression and correlation of them in laryngeal squamous cell carcinoma.Methods: The expression of VEGF, PD-ECGF and COX-2 was determined with S-P immunohistochemical analysis in 76 primary laryngeal carcinoma patients and 15 patients with polyp of larynx, and the associations of these proteins with pathological and clinical features were statistically analyzed.Results: Positive rates of VEGF(63.16%), PD-ECGF (57.89%)and COX-2(51.32%) in laryngeal carcinoma were significantly higher than those in polyp of larynx (P<0.01) . The positive expression of VEGF, PD-ECGF and COX-2 in laryngeal carcinoma was correlated with the tumor differentiation and invasive depth (P<0.05 ) . The positive expression of VEGF in laryngeal carcinoma was related tolamph node metastasis (P<0.01) .There were positive correlations between the expression of VEGF and COX-2 (P<0.05) , PD-ECGF and COX-2 (P<0.01) .Conclusion: VEGF, PD-ECGF and COX-2 may play a key role in laryngeal carcinoma. All may have close relation in angiogenesis and may provide new targets for therapy of laryngeal carcinoma.