Correlation Of Angiotensin-converting Enzyme Gene And CD14/-159 Polymorphism With Allergic Rhinitis

Objective:Allergic rhinitis(AR) has a complex genetic background.It is generally considered to be caused by the interaction of genetic and environmental factors . The patients with allergic rhinitis are characterized by an elevated and prolonged immunoglobulin E (IgE) antibody response after exposure to ubiquitous, nonpathogenic allergens. The genetic basis of allergic rhinitis is still a matter of intensive research and efforts have been expended in mapping the chromosomal locations of the susceptibility genes .We aimed to investigate the correlation of angiotensin-converting enzyme (ACE) gene polymorphism and -159C/T polymorphism of CD14 gene promoter with AR and want to approach its pathogenesis for guiding future therapies.Methods:60 allergic rhinitis patients (the allergic rhinitis group) and 40 health control (the control group) were recruited . Polymerase chain reaction techniques were used to determine the ACE genotype polymorphism and PCR-RFLP(restriction fragment length polymorphism) techniques were used to detect promoter polymorphism of CD14/-159 genotyping. Hardy-weinburg equilibrium and a series of statistic were used to analyses the experimental results.Results:...