The Analysis Of 222 Preliminary Diagnositic Asthmatic Children' Bone Mass And Effects Of Inhaled Corticosteoids On Bone Mass

Objective: To explore the relationsphip between bone mineral content(BMC), bone mineral density (BMD) and body height, body weight , lung function of preliminary Diagnositic asthmatic children,also initial evaluate the effect of inhaled corticosteroids on bone mineral content(BMC) and bone mineral density(BMD). Methods:1. 222 preliminary Diagnositic asthmatic children and 32 normal control children of Shandong Provincial Hospital,including pediatric hospital and out patients,was involved. Norland XR-36 Bone Densitometry Equipment was used to measure the BMC and BMD of L_2-4 by technologist. We also rechecked the bone mass of 20 patients who receieved regular fluticasone propionate management one years later.2. 52 random preliminary Diagnositic asthmatic children' PEF and FEV₁ was measured by Germany Jaeger lung function equipment,and children were divided into three group :mild group(PEF or FEV₁ > 80% of prediction value),moderate group(PEF or FEV₁ holds 60%⁸0% of prediction value),severe group(PEF or FEV₁ < 60% of prediction value).Result :1. The correlation between BMC, BMD and body height, body weight of preliminary Diagnositic asthmatic children and 32 normal control children is significant at the 0.01 level (2-tailed),and body height has the better correlation than body weight.2. The bone mass Z-SCORE of different lung function groups has not statistically significant(The LSD-t p value between mild group and moderate group,mild groupand severe group,moderate group and severe group was 0.134,0.505,0.503respectively,all the walue of p>0.05).3. The changes of bone mass and standardized bone mass , before using luticasonepropionate and one years later ,has not statistically significant (p>0.05) .Conclusion : There are better correlation between bone mass and body height > bodyheight.In order to clinical comparison,bone mass may be standardized.There are nostatistically significant of the bone mass among different lung function groups,different degree of asthma has no significiant effect on bone metabolism;The effect oflong-term ICS therapy on bone mass is not significant.