The Study Of The Predictable Value Of Homocysteine, Folic Acid, VitaminB₁₂ Levels In Xingjiang Uygur's And Hanzu's Patients With Coronary Heart Disease

Objective: To explore the predictable value of homocysteine(Hcy) in xingjiang uygur's and hanzu's patients with coronary heart disease and explore the relation between homocysteine and folic acid, vitaminB₁₂ levels by analyzing homocysteine, folic acid and vitaminB₁₂ levels in hanzu's patients and uygur's patients with coronary heart disease comparatively. Methods:Plasma Hcy, folic acid and vitaminB₁₂ levels of 162 patients(coronary heart disease group) and 114 normal controls (control group) were detected by enzymeconversion immunoassay. Resultes: â‘ Plasma Hcy levels in hanzu's patients were higher than those in the controls(16.55±8.34umol/L VS 10.58±6.71umol/L, P<0.05). The cases of hyperhomocysteinemia in the patients were more than those in the controls(54.37%VS 13.79%, P<0.05). Plasma Hcy levels in uygur patients were higher than those in the controls(15.25±7.02umol/L VS 11. 44±3.88μmol/L, P<0.05). The cases of hyperhomocysteinemia (53.57%) in the patients were more than those in the controls(53.57% VS 16.95%, P <0.05). Hcy level in uygur(hanzu)'s male patients were significantly higher than that in the controls and some differences were also noted between female patients and female controls. There are significantly differences between hanzu's male patients(controls) and hanzu's female patients(controls) in xingjiang in homocysteine level. â‘¡ Plasma folic acid level in the uygur(hanzu) male was lower than that in the female controls, and Plasma folic acid level in the uygur male patients was lowerthan that in the uygur male controls (4.62±1.23ng/ml VS 6.53±3.46ng/ml, P<0.05). Plasma folic acid level in the uygur male patients was lower than that in the hanzu male patients(4.62±1.23ng/ml VS 5.88±2.58ng/ml, P<0.05). Plasma folic acid level in the uygur female controls was lower than that in the hanzu female controls(6.82±2.58ng/ml VS 9.12±4.70ng/ml, P<0.05). (3) Plasma Hey levels in hanzu patients with coronary heart disease (CHD) was negative line correlation with plasma folic acid level in the hanzu patients with CHD. There was no correlation between plasma Hey levels and plasma folic acid level in uygur patients ?For vitaminBi2 level, there was no significant difference in each group. ConclusionrHcy level in xinjiang hanzu 's patients and uygur's patients with CHD was significantly higher than that in the normal controls, and the incidence of hyperhomocysteinemia was higher. There is no significantly difference between uygur's patients and hanzu's patients in xingjiang in homocys-teine. The influence of homocysteine and folic acid were more obvious in the male and there is negative line correlation between plasma Hey levels in hanzu paitient with CHD and folic acid level...