Homocysteine In Patients With Coronary Heart Disease And Blood Lipid Of Correlation Analysis And The Related Drug Curative Effect Evaluation

Purpose: Through to the coronary heart disease (CHD) patientswith serum homocysteine and the determination of blood lipids, analysisof both the correlation and influence on coronary artery stenosis, and onthis basis to explore the diagnosis and treatment in clinical on folic acidand the curative effect of statins for coronary heart disease andprevention.Methods: Selection of object of study for hospital betweenSeptember2012and April2012jilin university fellowship between Chinaand Japan after the hospital heart121with routine coronary angiographyexamination diagnosis of patients with coronary heart disease, accordingto the result of coronary angiography showed that the selection of patients,respectively according to the degree of coronary stenosis and lesion countwas divided into two groups, according to the degree of pathologicalchanges can be divided into level1, level2and level3, according to thelesion count into1,2and3, respectively, between groups ofhomocysteine and the relationship between blood lipid, further serumhomocysteine and correlation analysis of all kinds of blood fat, according to the correlation coefficient of homocysteine and all kinds of blood lipidafter correlation, continue to explore in clinical treatment of folic acid andstatin efficacy in the treatment of coronary heart disease and prevention,coronary angiography positive groups of patients were randomly dividedinto four subgroups: the folic acid group, statins, folic acid+statin groupand the placebo group. Folic acid groups: pure oral folic acid tablets,statin groups: pure oral atorvastatin, folic acid+statin group: combinedoral folic acid and atorvastatin, Blank control group, not taking anymedication. Medicine, respectively, compared to before taking themedicine and16weeks after the serum homocysteine and lipid levels andcoronary artery stenosis. Application spss17.0statistical software,statistical analysis accord with normal distribution data applicationanalysis, t test does not conform to the normal distribution of dataapplications rank and inspection, measurement data with mean+/-standard deviation (x+s) said, P <0.05was statistically significant.Results: With the increase of coronary artery stenosis degree andthe count, TG, CHOL, LDL-L, LDL-L/HDL-L, CHOL/HDL-L thegrowth trend, Hcy, HDL-L is on the decline, apolA, apolB saw noobvious trend. Through correlation analysis, Hcy in patients withcoronary heart disease (CHD) except with apo1A and apo1B there is nostatistical correlation, and the rest of the several indexes of statistics areconnected, the Hcy and CHOL, TG, HDL, LDL-L, L, CHOL/HDL-L, LDL-L/HDL-L order correlation coefficient is0.330,0.222,0.577,0.433,0.525and0.546, Hcy and CHOL, TG, LDL-L, CHOL/HDL-L,LDL-L/HDL-L are positive correlation, show the CHOL, TG, LDL-L, CHOL/HDL-L, LDL-L/HDL-higher L with the rising of Hcy,negatively related to the HDL-L, show the HDL-l and decreased withthe increase of Hcy.Instructed drug selection for16weeks in patients with oral observation,observe each subgroup of Hcy and lipid found that folic acid reduceshomocysteine levels in serum, statins can reduce triglyceride (TG), totalcholesterol (CHOL) and total cholesterol/high density lipoproteinCHOL/HDL-L), are statistically significant.Each subgroup of patients with coronary angiography examination againafter16weeks,30patients refuse to review coronary angiography, theresults in table6,7, because the sample size is missing, t test, P>0.05, isnot statistically significant. But visible oral folic acid group, statin andfolic acid+statin group coronary angiography have improved, and theeffect of folic acid+statin group is better than the statin group, the effectof statin group is better than the folic acid group. In clinic, continuousoral folic acid and statins for a period of time, can improve the conditionof coronary artery stenosis, but not statistically significant.Conclusion: Homocysteine can reflect the severity of coronaryatherosclerosis. Homocysteine and except apolA and apolB lipid has significant correlation. Folic acid can reduce serum homocysteine levels.Folic acid and statins can improve vascular stenosis, but it still needsfurther validation.