Plasma Homocyseteine Levels And The Left Ventricular Systolic Function In Diabetes Patients With Coronary Atheroslerotic Heart Disease

Objective: To explore the relations of plasma homocysteine levels and the left ventricular systolic function in diabetes mellitus (DM) with coronary atheroslerotic heart disease (CAHD), pick out the biochemical marks that can be used for predicting the left ventricular systolic function and find a new feasible method of treating and preventing the left ventricular systolic failure .Methods: The plasma homocysteine levels in 120 cases were examined;and at the same time we did some routine tests including fast blood sugar, HbAlc, C-reacting protein, plasma creatinine , BUN, electrocardiogram , ultrasound cardiography. There are 32 in-patients in the group in DM with CAHD(group Ⅰ), 26 cases in the group of DM without CAHD (group Ⅱ), 32 cases in the group of CAHD without DM (group Ⅲ)and 30 cases in control group(group Ⅳ).Result: The occurrence rate of hyperhomocysteinemia (Hhcy) in group I is 28.2%, mean Hcy levels is 8.98(±4.27), mean left ventricular eject fraction (LEVF) is 0.52(±0.08).The occurrence rate of Hhcy in group II is 15.4%, mean Hcy levels is 7.37(±3.08),mean LEVF is 0.59(±0.03).The occurrence rate of Hhcy in group Ⅲ is 18.9%, mean Hcy levels is 7.98(±2.76), mean LEVF is 0.57(±0.04).The occurrence rate of Hhcy in group IV is 6.9%, mean Hcy levels is 6.816(± 2.98), mean LEVF is 0.60(±0.02).Conclusion: There is a significant difference between group I and the other groups (P<0.05),and the levels of the Hhcy is inversely related to LVEF. So it is benefit for treating DM with C AHD to emphasizing to screening the Hey.