The Effects Of ATP Infused Continuously On Effective Concentration Of Propofol Given By Target-controlled Infusion

Objective : This study was designed to evaluate the effects of ATP on target-effect concentration of propofol given by target-controlled infusion. Methods :45 ASA â… ^â…¡ patients undergoing general surgery, were randomly allocated to one of three groups with 15 patients in each group:in propofol group (group P) anaesthesia was induced with propofol given by Diprifusor/ TCI system 2ug.ml^-1, midazolam 0.06 mg.kg^-1, fentanyl 3 ug.kg^-1, vecuronium 0.12 mg.kg^-1;maintained with propofol given by TCI;In ATP group â… (group A1)and ATP group â…¡ (group A2) anaesthesia was induced with propofol given by Diprifusor/ TCI system in 2ug.ml^-1, midazolam 0.06mg.kg^-1, fentanyl 3 ug.kg^-1, vecuronium 0.12 mg.kg^-1 and maintained with propofol given by TCI and continuous ATP infusion at a rate of 0.3 mg.kg^-1.h^-1 or 0.6 mg.kg^-1 .h^-1 .BIS was maintained at 50 ± 5 by adjustment of targe-effect propofol concentration. EKG, HR, MAP, SPO₂, PetCO₂ BIS and target-effect propofol concentration were continuously monitored and recorded. Result:(1)target-effect propofol concentration in group P was significantly higher at every time than in group A1 and group A2(P<0.05), and it was significantly lower during anesthesia in group A2 than in group A1(P<0.05) . (2)MAP was significantly lower at inducing time in three groups than that before drug administrtion;then MAP was significant higher in operation period.The change of MAP was significantly lower in group A1and A2 than that in group P .(3) Recovery time has no significant difference in three groups.(4) the standard amount of propofol in group A2 is (4.52 ±1.42) mg.kg^-1.h^-1,less than that in group A1 and group P , (5.03 ± 1.18) mg.kg^-1.h^-1, (5.53 ± 0.37) mg.kg^-1.h^-1. Conclusion:Continuous infusion ATP can decrease the target-effect propofol concentration during inducing time and maintaining time.